Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Furthermore, enhancement of TLX activity, by either ectopic expression or ligand stimulation, could potently prevent doxorubicin-induced senescence in prostate cancer cells and also allow prostatic epithelial cells to escape oncogene-induced senescence induced either by activated oncogene H-Ras(G12V) or knockdown of tumour suppressor PTEN, via a mechanism of direct but differential transcriptional regulation of two senescence-associated genes, repression of CDKN1A and transactivation of SIRT1.
|
25557355 |
2015 |
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
KRAS mutations were detected in 4 (3%) of 117 tumors (3× G12D and 1 G12V mutation).One tumor had a PIK3CA E545K mutation.
|
23158210 |
2013 |
Neoplasms
|
|
0.030 |
GeneticVariation
|
BEFREE |
Each of three Ki-ras(G12V) transfectants responded to TGF-beta1 by an increase in proliferation and by decreasing the abundance of the Cdk inhibitor p21 and the tumor suppressor PTEN, whereas each of three wild-type Ki-ras transfectants remained unresponsive to TGF-beta1.
|
11029459 |
2001 |
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have developed a Drosophila lung cancer model by targeting Ras1(G12V)--alone or in combination with PTEN knockdown--to the Drosophila tracheal system.
|
26832408 |
2016 |
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have developed a Drosophila lung cancer model by targeting Ras1(G12V)--alone or in combination with PTEN knockdown--to the Drosophila tracheal system.
|
26832408 |
2016 |
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have developed a Drosophila lung cancer model by targeting Ras1(G12V)--alone or in combination with PTEN knockdown--to the Drosophila tracheal system.
|
26832408 |
2016 |
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
Introduction of normal PTEN together with H-Ras(G12V) into U251 glioblastoma cells reduced the PI3K-dependent activation of Akt, but had no effect on vacuolation.
|
17210246 |
2007 |
Childhood Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Introduction of normal PTEN together with H-Ras(G12V) into U251 glioblastoma cells reduced the PI3K-dependent activation of Akt, but had no effect on vacuolation.
|
17210246 |
2007 |
Adult Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Introduction of normal PTEN together with H-Ras(G12V) into U251 glioblastoma cells reduced the PI3K-dependent activation of Akt, but had no effect on vacuolation.
|
17210246 |
2007 |
Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Introduction of normal PTEN together with H-Ras(G12V) into U251 glioblastoma cells reduced the PI3K-dependent activation of Akt, but had no effect on vacuolation.
|
17210246 |
2007 |
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We now show that stable expression of oncogenic Ki-ras(G12V) c</span>onverts the HD6-4 colon cancer cell line from insensitive to TGF-beta1 to growth-promoted by TGF-beta1.
|
11029459 |
2001 |
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
We now show that stable expression of oncogenic Ki-ras(G12V) c</span>onverts the HD6-4 colon cancer cell line from insensitive to TGF-beta1 to growth-promoted by TGF-beta1.
|
11029459 |
2001 |