rs121434568, EGFR

N. diseases: 73
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Neoplasm Metastasis
CUI: C0027627
Disease: Neoplasm Metastasis
0.040 GeneticVariation BEFREE The 19del and L858R patients were similar regarding recurrent patterns, except on pleural/chest wall metastasis (26.0% vs. 12.2%, p = 0.007). 29026990 2018
Neoplasm Metastasis
CUI: C0027627
Disease: Neoplasm Metastasis
0.040 GeneticVariation BEFREE Furthermore, retrospective analysis of 121 patients with lung adenocarcinoma to examine associations between serum SFTPD levels and clinical outcome indicated that in TKI-treated patients with lung cancer harboring EGFR mutations, including Ex19del or L858R, high serum SFTPD levels correlated with a lower number of distant metastases and prolonged overall survival and progression-free survival. 28745320 2017
Neoplasm Metastasis
CUI: C0027627
Disease: Neoplasm Metastasis
0.040 GeneticVariation BEFREE No significant differences in pathological stage and metastasis status were found between EGFR wild-type and mutated cases, although EGFR mutation type was related to pathological type (p=0.00) - 19-del, L858R and other mutation types respectively occurred in 34.2%, 42.5% and 23.3% of adenocarcinomas, but in 14.3%, 0% and 85.7% of non-adenocarcinomas. 27039821 2016
Neoplasm Metastasis
CUI: C0027627
Disease: Neoplasm Metastasis
0.040 GeneticVariation BEFREE Eligible participants were adults (> 18 years) with NSCLC and EGFR mutations (exon 19 deletion or L858R mutation in exon 21) with no history of chemotherapy for metastatic disease (neoadjuvant or adjuvant chemotherapy ending ≥ 6 months before study entry was allowed). 22285168 2012