Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our case report uncovered the underling relationship between SCLC transformation and the T790M mutation, and the fluid biopsy approach may help overcome the problem of heterogeneity in acquired resistance to EGFR-tyrosine kinase inhibitors.
|
28723866 |
2017 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two T790-wild-type cancers underwent small cell lung cancer transformation; three T790M-positive cancers acquired EGFR amplification.
|
25934077 |
2015 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The mechanisms for acquired resistance include selection of the EGFR T790M mutation in approximately 50% of cases, and MET gene amplification, PIK3CA gene mutation, transdifferentiation into small-cell lung cancer and additional rare or unkown mechanisms.
|
23664448 |
2013 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, through an in-depth analysis of multiple EGFR-TKI refractory lesions obtained from an autopsy case, we observed a complementary relationship between SCLC transformation and EGFR T790M secondary mutation (resistance mutation).
|
26400668 |
2015 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients with both <i>TP53</i> and <i>EGFR</i> mutations before treatment had worse overall survival than those with only <i>EGFR</i> Patients who progressed without T790M had worse PFS during TKI continuation and developed alternative alterations, including small-cell lung cancer-associated copy number changes and <i>TP53</i> mutations, that tracked subsequent treatment responses.
|
29848757 |
2018 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The mechanism of the first-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) acquired resistance included T790M mutation, cellular-mesenchymal to epithelial transition factor (MET) or EGFR amplification, PIK3CA mutation, and transformation to small cell lung cancer.
|
29505507 |
2018 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, this advanced EGFR-mutated NSCLC displayed very rapid onset and heterogeneous genetic and phenotypic mechanisms of TKI-resistance occurring at different times and locations of metastatic disease: concomitant FGFR3-mutation before and during TKI-treatment as potential intrinsic mechanism for the rapid progression; transformation to SCLC at first progression during TKI-therapy; acquired T790M EGFR-mutation at second progression.
|
29110841 |
2017 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several mechanisms of resistance to TKI have been described, threonine-methionine substitution at position 790 (T790M), mesenchymal-epithelial transition factor (MET) amplification, overexpression of hepatocyte growth factor (HGF), upregulation of insulin-like growth factor (IGF) receptor signaling, transformation to small cell lung cancer, and so on.
|
24316558 |
2014 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Clinically, EGFR-positive NSCLC acquires several resistance mechanisms during EGFR-TKI treatment, such as the emergence of a secondary mutation (T790M), MET gene amplification, and transformation to small cell lung cancer.
|
30290647 |
2018 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Pre-TKI and post-TKI biopsies from 27 patients with an activating EGFR mutation were collected and analyzed for EGFR-T790M mutation, MET amplification, and SCLC transformation.
|
31644442 |
2019 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
This patient acquired resistance to first-generation EGFR-TKIs through small cell lung cancer (SCLC) transformation accompanied by the T790M mutation.
|
30521113 |
2019 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The carcinoma in seven patients transformed to small cell lung carcinoma; two of these patients enrolled in theAZD9291 study after acquiring a T790M missense mutation.
|
29120087 |
2018 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Subsequently, the right thoracic wall tumor harboring T790M and the right pleural tumor near the diaphragm showing transformation to SCLC exhibited opposite responses to therapy alternating between osimertinib and chemotherapy.
|
30603652 |
2018 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
EGFR T790M secondary mutation, MET gene amplification, and transformation to small cell lung cancer are well-validated mechanisms that underlie acquisition of resistance to EGFR-TKIs.
|
24939008 |
2014 |
Small cell carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several mechanisms for this acquired resistance have been identified, including development of an EGFR T790M mutation, MET amplification, hepatocyte growth factor overexpression, loss of phosphatase and tensin homolog expression, epithelial-mesenchymal transition, and transformation to small cell lung cancer.
|
28786540 |
2017 |