Disease: Carcinoma, Small Cell ×
Source: BEFREE ×
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Carcinoma, Small Cell
CUI: C0262584
Disease: Carcinoma, Small Cell
0.020 GeneticVariation BEFREE A case of resistance to tyrosine kinase inhibitor therapy: small cell carcinoma transformation concomitant with plasma-genotyped T790M positivity. 28723866 2017
Carcinoma, Small Cell
CUI: C0262584
Disease: Carcinoma, Small Cell
0.020 GeneticVariation BEFREE At present, secondary resistance mechanisms associated with progression are better known: clonal selection of EGFR resistance mutation (T790M mutation in exon 20), amplification of transmembrane receptors for other growth factors (c-met, HER family, IGF1R, or AXL), downstream molecular alterations in EGFR signaling pathway (PI3K or PTEN), and epithelial-mesenchymal transition or transdifferentiation to small-cell cancer. 23911281 2013