Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
UNIPROT |
|
|
|
leukemia
|
|
0.050 |
GeneticVariation
|
BEFREE |
They described a novel point mutation (E17K) in the pleckstrin homology domain (PHD) of the AKT1 gene in human breast, colorectal and ovarian cancers, and demonstrated that it induces leukemia in mice.
|
17921701 |
2007 |
Malignant neoplasm of ovary
|
|
0.030 |
GeneticVariation
|
BEFREE |
They described a novel point mutation (E17K) in the pleckstrin homology domain (PHD) of the AKT1 gene in human breast, colorectal and ovarian cancers, and demonstrated that it induces leukemia in mice.
|
17921701 |
2007 |
Childhood Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
They described a novel point mutation (E17K) in the pleckstrin homology domain (PHD) of the AKT1 gene in human breast, colorectal and ovarian cancers, and demonstrated that it induces leukemia in mice.
|
17921701 |
2007 |
Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The activity of the endogenous kinase carrying the E17K mutation immunoprecipitated by tumour tissue was significantly higher compared with the wild-type kinase immunoprecipitated by the adjacent normal tissue as determined both by in vitro kinase assay using a consensus peptide as substrate and by in vivo analysis of the phosphorylation status of AKT1 itself (pT308, pS473) or of known downstream substrates such as GSK3 (pS9/S22) and p27 (T198).
|
18256540 |
2008 |
Malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our data provide evidence that, although AKT1 mutations are apparently rare in lung cancer (1.9%), the oncogenic properties of E17K-AKT1 may contribute to the development of a fraction of lung carcinoma with squamous histotype (5.5%).
|
18256540 |
2008 |
Adenocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We detected a missense mutations G-->A transition at nucleotide 49 (that results in the E17K substitution) in two squamous cell carcinoma (2/36) but not in adenocarcinoma (0/53).
|
18256540 |
2008 |
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We detected a missense mutations G-->A transition at nucleotide 49 (that results in the E17K substitution) in two squamous cell carcinoma (2/36) but not in adenocarcinoma (0/53).
|
18256540 |
2008 |
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data provide evidence that, although AKT1 mutations are apparently rare in lung cancer (1.9%), the oncogenic properties of E17K-AKT1 may contribute to the development of a fraction of lung carcinoma with squamous histotype (5.5%).
|
18256540 |
2008 |
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data provide evidence that, although AKT1 mutations are apparently rare in lung cancer (1.9%), the oncogenic properties of E17K-AKT1 may contribute to the development of a fraction of lung carcinoma with squamous histotype (5.5%).
|
18256540 |
2008 |
Squamous cell carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung.
|
18256540 |
2008 |
Malignant neoplasm of breast
|
|
0.770 |
GeneticVariation
|
BEFREE |
This study demonstrated that the AKT1 E17K mutation occurs in breast cancers at a low frequency, and that it is rare in other common cancers, including colorectal, lung, gastric and hepatocellular carcinomas and acute leukaemias.
|
18392055 |
2008 |
Malignant Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
Overall, we detected the four AKT1 E17K</span> mutations in the breast cancers (4/93; 4.3%), but none in other cancers.
|
18392055 |
2008 |
Malignant neoplasm of ovary
|
|
0.030 |
GeneticVariation
|
BEFREE |
An earlier study discovered an oncogenic AKT1 gene mutation (AKT1 E17K) in breast, colorectal and ovarian cancers.
|
18392055 |
2008 |
Primary malignant neoplasm
|
|
0.030 |
GeneticVariation
|
BEFREE |
We analysed the presence of the AKT1 E17K mutation in 731 cancer tissues by a single-strand conformation polymorphism assay.
|
18392055 |
2008 |
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrated that the AKT1 E17K mutation occurs in breast cancers at a low frequency, and that it is rare in other common cancers, including colorectal, lung, gastric and hepatocellular carcinomas and acute leukaemias.
|
18392055 |
2008 |
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrated that the AKT1 E17K mutation occurs in breast cancers at a low frequency, and that it is rare in other common cancers, including colorectal, lung, gastric and hepatocellular carcinomas and acute leukaemias.
|
18392055 |
2008 |
leukemia
|
|
0.050 |
GeneticVariation
|
BEFREE |
The E17K change results in constitutive AKT1 activation and induces leukaemia in mice.
|
18504432 |
2008 |
Malignant neoplasm of ovary
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recently, a somatic mutation in AKT1 (E17K) has been detected in breast, colorectal, lung and ovarian cancers.
|
18504432 |
2008 |
leukemia
|
|
0.050 |
GeneticVariation
|
BEFREE |
The transforming mutation E17K/AKT1 is not a major event in B-cell-derived lymphoid leukaemias.
|
18665177 |
2008 |
Malignant Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
Despite the major role of the AKT/PKB family of proteins in the regulation of many growth and survival mechanisms in the cell, and the increasing evidence suggesting that AKT disruption could play a key role in many human malignancies, no major mutations of AKT genes had been reported, until very recently when Carpten et al reported a novel transforming mutation (E17K) in the pleckstrin homology domain of the AKT1 gene in solid tumours.
|
18665177 |
2008 |
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation
|
BEFREE |
AKT1 (E17K) mutation in pancreatic cancer.
|
18783292 |
2008 |
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
AKT1 (E17K) mutation in pancreatic cancer.
|
18783292 |
2008 |
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recently, a rare activating mutation of AKT1 (E17K) has been reported in breast, ovarian, and colorectal cancers.
|
18813315 |
2008 |
melanoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To determine the prevalence of AKT E17K mutations in melanoma, the most aggressive form of skin cancer, we analysed 137 human melanoma specimens and 65 human melanoma cell lines for the previously described activating mutation of AKT1, and for analogous mutations in AKT2 and AKT3.
|
18813315 |
2008 |