rs1217691063, MTHFR

N. diseases: 614
Disease: Pancreatic carcinoma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Pancreatic carcinoma
CUI: C0235974
Disease: Pancreatic carcinoma
0.050 GeneticVariation BEFREE MTHFR gene C677T rather than A1298C polymorphism may be associated with PC. 31701291 2020
Pancreatic carcinoma
CUI: C0235974
Disease: Pancreatic carcinoma
0.050 GeneticVariation BEFREE We performed a meta-analysis of all relevant case-control studies that examined the association between MTHFR C677T polymorphism and pancreatic cancer risk. 23098468 2012
Pancreatic carcinoma
CUI: C0235974
Disease: Pancreatic carcinoma
0.050 GeneticVariation BEFREE The risk for PC was higher in individuals with MTHFR C677T or TT polymorphisms and a smoking habit (OR = 2.52, 95% CI = 1.05-6.09, P = 0.04). 21441790 2011
Pancreatic carcinoma
CUI: C0235974
Disease: Pancreatic carcinoma
0.050 GeneticVariation BEFREE We conducted a case-control study to assess the effect of alcohol on pancreatic cancer in conjunction with polymorphisms in one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G), and thymidylate synthase (TS) variable number of tandem repeat. 18843018 2008
Pancreatic carcinoma
CUI: C0235974
Disease: Pancreatic carcinoma
0.050 GeneticVariation BEFREE Joint effect between MTHFR C677T polymorphism and smoking or drinking increased risk of pancreatic cancer in a super-multiplicative manner. 16234002 2005