Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
Malignant neoplasm of breast
|
0.700 | GeneticVariation | CLINVAR | CHEK2 mutations and the risk of papillary thyroid cancer. | 25583358 | 2015 | |||||
Malignant neoplasm of breast
|
0.700 | GeneticVariation | CLINVAR | CHEK2 is a multiorgan cancer susceptibility gene. | 15492928 | 2004 | |||||
BREAST AND COLORECTAL CANCER, SUSCEPTIBILITY TO
|
0.700 | CausalMutation | CLINVAR | ||||||||
Malignant neoplasm of breast
|
0.700 | GeneticVariation | CLINVAR | Association of Germline CHEK2 Gene Variants with Risk and Prognosis of Non-Hodgkin Lymphoma. | 26506619 | 2015 | |||||
Malignant neoplasm of breast
|
0.700 | GeneticVariation | CLINVAR | RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease. | 25525159 | 2015 | |||||
Malignant neoplasm of breast
|
0.700 | CausalMutation | CLINVAR | Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer. | 21876083 | 2011 | |||||
Malignant neoplasm of breast
|
0.700 | CausalMutation | CLINVAR | Mutations in CHEK2 associated with prostate cancer risk. | 12533788 | 2003 | |||||
Neoplastic Syndromes, Hereditary
|
0.700 | CausalMutation | CLINVAR | The germline mutations of the CHEK2 gene are associated with an increased risk of polycythaemia vera. | 26084796 | 2016 | |||||
Malignant neoplasm of breast
|
0.700 | GeneticVariation | CLINVAR | Limited relevance of the CHEK2 gene in hereditary breast cancer. | 15095295 | 2004 | |||||
Neoplastic Syndromes, Hereditary
|
0.700 | CausalMutation | CLINVAR | Synergistic interaction of variants in CHEK2 and BRCA2 on breast cancer risk. | 19030985 | 2009 | |||||
Malignant neoplasm of breast
|
0.700 | CausalMutation | CLINVAR | Hereditary truncating mutations of DNA repair and other genes in BRCA1/BRCA2/PALB2-negatively tested breast cancer patients. | 26822949 | 2016 | |||||
Neoplastic Syndromes, Hereditary
|
0.700 | CausalMutation | CLINVAR | Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer. | 21876083 | 2011 | |||||
Malignant neoplasm of breast
|
0.700 | GeneticVariation | CLINVAR | Association of two mutations in the CHEK2 gene with breast cancer. | 15810020 | 2005 | |||||
Malignant neoplasm of breast
|
0.700 | CausalMutation | CLINVAR | Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer. | 27153395 | 2016 | |||||
Neoplastic Syndromes, Hereditary
|
0.700 | CausalMutation | CLINVAR | Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome. | 25980754 | 2015 | |||||
Neoplastic Syndromes, Hereditary
|
0.700 | CausalMutation | CLINVAR | The risk of gastric cancer in carriers of CHEK2 mutations. | 23296741 | 2013 | |||||
Malignant neoplasm of breast
|
0.700 | GeneticVariation | CLINVAR | Analysis of CHEK2 FHA domain in Czech patients with sporadic breast cancer revealed distinct rare genetic alterations. | 18058223 | 2008 | |||||
Malignant neoplasm of breast
|
0.700 | GeneticVariation | CLINVAR | A risk of breast cancer in women - carriers of constitutional CHEK2 gene mutations, originating from the North - Central Poland. | 24713400 | 2014 | |||||
Malignant neoplasm of prostate
|
0.700 | CausalMutation | CLINVAR | ||||||||
Malignant neoplasm of breast
|
0.700 | CausalMutation | CLINVAR | Gene panel sequencing in familial breast/ovarian cancer patients identifies multiple novel mutations also in genes others than BRCA1/2. | 27616075 | 2017 | |||||
BREAST CANCER, SUSCEPTIBILITY TO
|
0.700 | CausalMutation | CLINVAR | ||||||||
Malignant neoplasm of breast
|
0.700 | GeneticVariation | CLINVAR | A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer. | 17085682 | 2006 | |||||
Malignant neoplasm of breast
|
0.700 | GeneticVariation | CLINVAR | Mutations in CHEK2 associated with prostate cancer risk. | 12533788 | 2003 | |||||
Malignant neoplasm of breast
|
0.700 | GeneticVariation | CLINVAR | Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer. | 21876083 | 2011 | |||||
Li-Fraumeni Syndrome 2
|
0.700 | CausalMutation | CLINVAR |