DisGeNET - a database of gene-disease associations

Summary of VDAs
Evidences for VDAs

rs121909646, FLT3

N. diseases: 3

Disease: Leukemia, Myelocytic, Acute ×

Source: ALL

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Leukemia, Myelocytic, Acute

CUI:	C0023467
Disease:	Leukemia, Myelocytic, Acute

0.700

CausalMutation

CLINVAR

Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia.

24046014

2013

Leukemia, Myelocytic, Acute

CUI:	C0023467
Disease:	Leukemia, Myelocytic, Acute

0.700

CausalMutation

CLINVAR

Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

25157968

2014