rs121912431, SOD1

N. diseases: 11
Disease: Neuroblastoma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Neuroblastoma
CUI: C0027819
Disease: Neuroblastoma
0.040 GeneticVariation BEFREE Here, we show that stable overexpression of mutant human SOD1 (G37R) - but not wild-type SOD1 (wt-SOD1) - in mouse neuroblastoma cells (N2a) results in morphological abnormalities of mitochondria accompanied by several dysfunctions. 21388680 2011
Neuroblastoma
CUI: C0027819
Disease: Neuroblastoma
0.040 GeneticVariation BEFREE Previously, we reported that overexpression of the mitochondrial antioxidant manganese superoxide dismutase (MnSOD or SOD2) attenuates cytotoxicity induced by expression of the G37R-SOD1 mutant in a human neuroblastoma cell culture model of ALS. 17394531 2007
Neuroblastoma
CUI: C0027819
Disease: Neuroblastoma
0.040 GeneticVariation BEFREE Mouse neuroblastoma Neuro-2a cells were transfected with human wild-type or mutated (G37R, G93A) Cu,Zn-SOD. 15456693 2005
Neuroblastoma
CUI: C0027819
Disease: Neuroblastoma
0.040 GeneticVariation BEFREE Expression of mutant SOD1 (G37R) resulted in a time and dose-related death of differentiated neuroblastoma cells. 12067230 2002