|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
(4) Conclusion: Besides the established histaminergic neuroprotective and anti-inflammatory effects, the induction of the heat shock response in the SOD1-G93A model by histamine confirms the importance of this pathway in the search for successful therapeutic solutions to treat ALS.
|
31382568 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
G93A SOD1 alters cell cycle in a cellular model of Amyotrophic Lateral Sclerosis.
|
20561900 |
2010 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
G93A SOD1 expression in motor neurons of C. elegans results in characteristic alterations of ALS.
|
23503474 |
2013 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A major QTL on mouse chromosome 17 resulting in lifespan variability in SOD1-G93A transgenic mouse models of amyotrophic lateral sclerosis.
|
25008789 |
2014 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A monoclonal antibody, clone C4F6 - raised against the ALS variant G93A of SOD1, has been identified as specifically recognizing a conformation shared by many ALS mutants of SOD1.
|
24887207 |
2014 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A proteomic analysis of protein expression in a widely used mouse model of ALS was undertaken to identify differences in protein expression in the spinal cords of mice expressing a mutant protein with the G93A mutation found in human ALS.
|
16571896 |
2006 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A structure activity relationship of a lead scaffold exhibiting neuroprotective activity in a G93A-SOD1 mouse model for ALS has been further investigated in a model PC12 cellular assay.
|
23021992 |
2012 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
A transgenic mouse model of amyotrophic lateral sclerosis was selected based on a phenotype resembling clinical symptoms, including loss of motor neurons from the spinal cord and paralysis in one or more limbs, due to expression of a G93A mutant form of human superoxide dismutase (SOD1).
|
23383983 |
2013 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Abnormal medial prefrontal cortex connectivity and defective fear extinction in the presymptomatic G93A SOD1 mouse model of ALS.
|
18081837 |
2008 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Accumulation of DNA damage has been detected in the spinal cord of patients as well as in the G93A mouse model of amyotrophic lateral sclerosis (ALS).
|
31676238 |
2020 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression.
|
27549088 |
2016 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Acute glial activation by stab injuries does not lead to overt damage or motor neuron degeneration in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis.
|
20005223 |
2010 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice.
|
18648532 |
2008 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Adenosine A2A receptors activation facilitates neuromuscular transmission in the pre-symptomatic phase of the SOD1(G93A) ALS mice, but not in the symptomatic phase.
|
25093813 |
2014 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Adipose-derived stem cell conditioned medium impacts asymptomatic peripheral neuromuscular denervation in the mutant superoxide dismutase (G93A) transgenic mouse model of amyotrophic lateral sclerosis.
|
30010155 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Adverse effects of a SOD1-peptide immunotherapy on SOD1 G93A mouse slow model of amyotrophic lateral sclerosis.
|
26384962 |
2015 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although viral delivery of IGF-I has shown therapeutic efficacy in the SOD1(G93A) mouse model of ALS, clinical trials of IGF-I in ALS patients have led to conflicting results.
|
19038252 |
2009 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Altogether these findings indicate that G93A-SOD1 expression results in an exacerbated pattern of neuroinflammation and suggest that C/EBPβ is a candidate to regulate the expression of potentially neurotoxic genes in microglial cells in ALS.
|
22015310 |
2012 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Amyloid precursor protein (APP) contributes to pathology in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
|
22678056 |
2012 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
An Allosteric Pathway in Copper, Zinc Superoxide Dismutase Unravels the Molecular Mechanism of the G93A Amyotrophic Lateral Sclerosis-Linked Mutation.
|
31747286 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis.
|
21095130 |
2011 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
As a model for amyotrophic lateral sclerosis (ALS), transgenic hSOD1(G93A) mice constitute the standard tool for evaluating future therapeutic strategies.
|
21723884 |
2011 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
As a result, genistein alleviated ALS-related symptoms and slightly prolonged the lifespan of SOD1-G93A mice.
|
31321663 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
As proof of concept, we use the IS paradigm to express murine Interleukin (IL)-10 in the spinal cord of the SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis.
|
25228069 |
2015 |
|
Amyotrophic Lateral Sclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Astrocyte dysfunction also occurs in human ALS and transgenic rodents expressing mutant human SOD1 protein (SOD1(G93A)).
|
18931666 |
2008 |