Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
melanoma
|
0.700 | CausalMutation | CLINVAR | Sunitinib therapy for melanoma patients with KIT mutations. | 22261812 | 2012 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Sunitinib therapy for melanoma patients with KIT mutations. | 22261812 | 2012 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | KIT as a therapeutic target in metastatic melanoma. | 21642685 | 2011 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. | 21690468 | 2011 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | KIT as a therapeutic target in metastatic melanoma. | 21642685 | 2011 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. | 21690468 | 2011 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Response to imatinib mesylate depends on the presence of the V559A-mutated KIT oncogene. | 19812602 | 2010 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Response to imatinib mesylate depends on the presence of the V559A-mutated KIT oncogene. | 19812602 | 2010 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates. | 19671763 | 2009 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates. | 19671763 | 2009 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | KIT gene mutations and copy number in melanoma subtypes. | 18980976 | 2008 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation. | 18510589 | 2008 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | KIT gene mutations and copy number in melanoma subtypes. | 18980976 | 2008 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Major response to imatinib mesylate in KIT-mutated melanoma. | 18421059 | 2008 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Complete response of stage IV anal mucosal melanoma expressing KIT Val560Asp to the multikinase inhibitor sorafenib. | 18936790 | 2008 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Complete response of stage IV anal mucosal melanoma expressing KIT Val560Asp to the multikinase inhibitor sorafenib. | 18936790 | 2008 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Major response to imatinib mesylate in KIT-mutated melanoma. | 18421059 | 2008 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation. | 18510589 | 2008 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition. | 17372901 | 2007 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition. | 17372901 | 2007 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412. | 15790786 | 2005 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412. | 15790786 | 2005 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours. | 11276010 | 2001 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours. | 11276010 | 2001 | |||||
melanoma
|
0.700 | CausalMutation | CLINVAR | Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. | 9438854 | 1998 |