rs121913237, NRAS

N. diseases: 50
Disease: leukemia ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
leukemia
CUI: C0023418
Disease: leukemia
0.020 GeneticVariation BEFREE In a multiplexed analysis of RAS-dependent signaling, Mac-1(Low) cells, which harbor leukemia stem cells, were preferentially sensitive to NRAS(G12V) withdrawal. 25316678 2014
leukemia
CUI: C0023418
Disease: leukemia
0.020 GeneticVariation BEFREE Injecting Mx1-Cre, LSL-Nras(G12D) mice with the MOL4070LTR retrovirus causes acute myeloid leukemia that faithfully recapitulates many aspects of human NRAS-associated leukemias, including cooperation with deregulated Evi1 expression. 21163920 2011