rs121913240, KRAS

N. diseases: 24
Disease: Skin Carcinogenesis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Skin Carcinogenesis
CUI: C1519346
Disease: Skin Carcinogenesis
0.010 GeneticVariation BEFREE In a mouse model of HRAS Q61L-mediated skin carcinogenesis, the vemurafenib analogue PLX4720 was not an initiator or a promoter of carcinogenesis but accelerated growth of the lesions harboring HRAS mutations, and this growth was blocked by concomitant treatment with a MEK inhibitor. 22256804 2012