Colorectal Carcinoma
|
|
0.800 |
CausalMutation
|
CLINVAR |
|
|
|
THYROID CANCER, NONMEDULLARY, 2
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
melanoma
|
|
0.720 |
GeneticVariation
|
CLINVAR |
Mutations of the BRAF gene in human cancer.
|
12068308 |
2002 |
Non-Small Cell Lung Carcinoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
Mutations of the BRAF gene in human cancer.
|
12068308 |
2002 |
Colorectal Carcinoma
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status.
|
12198537 |
2002 |
Follicular adenoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
A distinct mutation in BRAF (codon K600E) was detected in a follicular adenoma.
|
12881714 |
2003 |
Thyroid Gland Follicular Adenoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
A distinct mutation in BRAF (codon K600E) was detected in a follicular adenoma.
|
12881714 |
2003 |
melanoma
|
|
0.720 |
GeneticVariation
|
CLINVAR |
Determinants of BRAF mutations in primary melanomas.
|
14679157 |
2003 |
Papillary thyroid carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
A distinct mutation in BRAF (codon K600E) was detected in three cases of the follicular variant of PTC.
|
14743508 |
2004 |
Neoplasms
|
|
0.780 |
GeneticVariation
|
CLINVAR |
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.
|
15035987 |
2004 |
Papillary thyroid carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is apparently restricted to the follicular variant of PTC.
|
15095090 |
2004 |
Papillary thyroid carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Moreover, there is a close association between the type of mutation and the PTC histotype: BRAF(V600E) is associated with conventional PTC and with histological variants of PTC displaying a prominent papillary growth pattern, whereas BRAF(K601E) is associated with the follicular variant of PTC.
|
16021577 |
2005 |
Secondary Neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Further studies are necessary to clarify the putative clinical significance (e.g. association to blood-born metastases) of PAX8-PPARgamma rearrangement, RAS mutations, and BRAF(K601E) in FVPTCs.
|
16219715 |
2006 |
Follicular Variant Thyroid Gland Papillary Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Further studies are necessary to clarify the putative clinical significance (e.g. association to blood-born metastases) of PAX8-PPARgamma rearrangement, RAS mutations, and BRAF(K601E) in FVPTCs.
|
16219715 |
2006 |
Neoplasm Metastasis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Further studies are necessary to clarify the putative clinical significance (e.g. association to blood-born metastases) of PAX8-PPARgamma rearrangement, RAS mutations, and BRAF(K601E) in FVPTCs.
|
16219715 |
2006 |
Cardio-facio-cutaneous syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome.
|
16439621 |
2006 |
Cardio-facio-cutaneous syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.
|
16474404 |
2006 |
Cardio-facio-cutaneous syndrome
|
|
0.800 |
CausalMutation
|
CLINVAR |
KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression.
|
16953233 |
2007 |
Noonan Syndrome
|
|
0.700 |
CausalMutation
|
CLINVAR |
KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression.
|
16953233 |
2007 |
Colorectal Carcinoma
|
|
0.800 |
GeneticVariation
|
UNIPROT |
ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer.
|
17060676 |
2006 |
Adenomatous Polyposis Coli
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report a case with a very rare deletion mutation of BRAF (c.1799-1801delTGA, p.Val600_Lys601delinsGlu) in a serrated adenoma; the patient has familial adenomatous polyposis with a germline mutation of the APC gene (c.3578delA, p.Gln1193ArgfsX1264).
|
17696956 |
2007 |
Papillary thyroid carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Surprisingly, we did not identify the previously reported VK600-1E or K601E mutations in our PTC specimens.
|
17824790 |
2007 |
Cardio-facio-cutaneous syndrome
|
|
0.800 |
GeneticVariation
|
UNIPROT |
Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome.
|
18042262 |
2008 |
Colorectal Carcinoma
|
|
0.800 |
GeneticVariation
|
UNIPROT |
National Academy of Clinical Biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers.
|
19042984 |
2008 |
Cardio-facio-cutaneous syndrome
|
|
0.800 |
CausalMutation
|
CLINVAR |
Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.
|
19206169 |
2009 |