|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
UNIPROT |
|
|
|
|
Adrenocortical carcinoma
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Adenocarcinoma of prostate
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Adenocarcinoma of pancreas
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Malignant Uterine Corpus Neoplasm
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Cutaneous Melanoma
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Adenocarcinoma of lung (disorder)
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Colorectal Neoplasms
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Hepatoblastoma
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
Desmoid Tumor Caused By Somatic Mutation
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
Additional adjustment for tumor size yielded a P-value of 0.082 with hazard ratio's of 0.83 [95% confidence interval (CI) 0.48-1.42), 0.37 (95% CI 0.12-1.14), and 0.44 (95% CI 0.21-0.92) for T41A, S45P and WT DTF tumors compared to S45F DTF tumors.
|
31804402 |
2019 |
|
Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
Furthermore, analysis of beta-catenin gene revealed that the tumor had a typical missense mutation of threonine to alanine at colon 41 (T41A) in exon 3.
|
26907785 |
2016 |
|
Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
The tumor carried a heterozygous p.T41A mutation in CTNNB1.
|
27213811 |
2016 |
|
Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
Tumor DNA analysis revealed a heterozygous ACC-to-GCC missense mutation in codon 41 (T41A) and a TCT-to-CCT missense mutation in codon 45 (S45P) of exon 3 of the beta-catenin gene that was confirmed at the cDNA level.
|
18419788 |
2008 |
|
Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
Molecular analysis of microdissected cells from the left tumour revealed the same S45P CTNNB1 mutation in blastema, tubuli, stroma and muscle, and a different CTNNB1 mutation (T41A) in stromal cells isolated from another area of the same slide.
|
17551084 |
2007 |
|
Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
Five carcinomas showed beta-catenin mutations (S37C, T41I, T41A), including 4 (33%) of 12 endometrioid-type tumors and 1 (14%) of 7 mucinous-type tumors.
|
10391090 |
1999 |
|
Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
Heterozygous substitution mutations at codon 37 in two cases (S37F and S37C) and at codon 41 in one case (T41A) were found in three endometrioid lesions (one borderline tumor and two carcinomas) with abnormal beta-catenin expression.
|
9537226 |
1998 |
|
Fibromatosis, Aggressive
|
|
0.060 |
GeneticVariation
|
BEFREE |
No statistically significant difference in relative expression levels of Wnt target genes AXIN2, DKK1 and CCND1 was identified between either CTNNB1 wild-type, S45F or T41A mutated DTF samples.
|
30528042 |
2019 |
|
Fibromatosis, Aggressive
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our findings suggest that the response to sorafenib differs when comparing S45F-mutated DTs and T41A-mutated or wild-type DTs.
|
30980399 |
2019 |
|
Fibromatosis, Aggressive
|
|
0.060 |
GeneticVariation
|
BEFREE |
The majority of desmoid tumors are related to T41A and S45F mutations of the beta-catenin encoding gene (CTNNB1).
|
29330550 |
2018 |
|
Fibromatosis, Aggressive
|
|
0.060 |
GeneticVariation
|
BEFREE |
We demonstrated that mutated DFs (T41A or S45F) and WT are two distinct molecular subgroups with regard to β-catenin stability, α-catenin affinity, and gene expression profiling.
|
28627792 |
2017 |
|
Fibromatosis, Aggressive
|
|
0.060 |
GeneticVariation
|
BEFREE |
Only 1 NMC had no detectable CTNNB1 mutation; however, the patient's subsequent NMC-fibromatosis had a CTNNB1 p.T41A mutation.
|
27259010 |
2016 |
|
Fibromatosis, Aggressive
|
|
0.060 |
GeneticVariation
|
BEFREE |
The other 3 patients showed a CTNNB1 mutation in the original desmoid-type fibromatosis (2 with a T41A and 1 with an S45F mutation), which was absent in the sarcoma.
|
26414222 |
2015 |
|
Fibromatosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Mutational analysis of exon 3 of the β-catenin gene (CTNNB1) revealed that mesenteric desmoids carried mutations significantly more often (51/56, 91.1%) than non-mesenteric tumours (20/28; 71.4%; P = 0.027). p.T41A occurred significantly more frequently in mesenteric fibromatoses (80.4%) than in abdominal wall and extra-abdominal fibromatoses (46.4%; P = 0.002).
|
23020601 |
2013 |