|
Leukemia, Myelocytic, Acute
|
|
0.720 |
GeneticVariation
|
BEFREE |
Rapid detection of IDH2 (R140Q and R172K) mutations in acute myeloid leukemia.
|
23949315 |
2013 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
GeneticVariation
|
BEFREE |
We found three missense (p.R132C, p.R132G, and p.I99M; occurred in five patients) and one silent mutation (c.315C>T; occurred in two patients) in the IDH1 gene and two missense mutations (p.R140Q and p.R172K; occurred in four AML patients) and one silent mutation (c.435G>A) in the IDH2 gene.
|
20946881 |
2010 |
|
GLIOMA SUSCEPTIBILITY 1
|
|
0.700 |
GeneticVariation
|
UNIPROT |
IDH2 mutation in gliomas including novel mutation.
|
25495392 |
2015 |
|
GLIOMA SUSCEPTIBILITY 1
|
|
0.700 |
GeneticVariation
|
UNIPROT |
IDH1 and IDH2 mutations in gliomas.
|
19228619 |
2009 |
|
oligodendroglioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
A c.515G>T (p.R172M) mutation of the IDH2 gene was only identified in a grade II oligodendroglioma patient which was wild-type for IDH1.
|
21643842 |
2011 |
|
oligodendroglioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).
|
25277207 |
2014 |
|
Angioimmunoblastic Lymphadenopathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development.
|
27956631 |
2016 |
|
Well Differentiated Oligodendroglioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
A c.515G>T (p.R172M) mutation of the IDH2 gene was only identified in a grade II oligodendroglioma patient which was wild-type for IDH1.
|
21643842 |
2011 |
|
Angioimmunoblastic Lymphadenopathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Expression of TFH Markers and Detection of RHOA p.G17V and IDH2 p.R172K/S Mutations in Cutaneous Localizations of Angioimmunoblastic T-Cell Lymphomas.
|
28945625 |
2017 |
|
Well Differentiated Oligodendroglioma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).
|
25277207 |
2014 |
|
Childhood Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overexpression of IDH1(R132H) and IDH2(R172K) mutant protein in glioblastoma cells resulted in increased radiation sensitivity and altered ROS metabolism and suppression of growth and migration in vitro.
|
23115158 |
2013 |
|
Adult Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The test evaluates the expression of 20 genes, including 17 markers relevant to T-cell immunology and lymphoma biopathology, one EBV-related transcript, and variants of RHOA (G17V) and IDH2 (R172K/T).
|
31488561 |
2019 |
|
Spindle cell hemangioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The R132C IDH1 mutation was identified by hydrolysis probes assay and confirmed by Sanger sequencing in 18 of 28 (64%) SCHs; of the 10 negative cases, 2 harbored a mutation in IDH2 (R172T and R172M) by Sanger sequencing.
|
23485734 |
2013 |
|
Childhood Anaplastic Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The R132H IDH1 mutation was identified in 43/117 tumor samples and R172K IDH2 mutation was detected in only one anaplastic oligodendroglioma.
|
27268645 |
2016 |
|
Adult Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overexpression of IDH1(R132H) and IDH2(R172K) mutant protein in glioblastoma cells resulted in increased radiation sensitivity and altered ROS metabolism and suppression of growth and migration in vitro.
|
23115158 |
2013 |
|
Adult Anaplastic Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The R132H IDH1 mutation was identified in 43/117 tumor samples and R172K IDH2 mutation was detected in only one anaplastic oligodendroglioma.
|
27268645 |
2016 |
|
Glioblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overexpression of IDH1(R132H) and IDH2(R172K) mutant protein in glioblastoma cells resulted in increased radiation sensitivity and altered ROS metabolism and suppression of growth and migration in vitro.
|
23115158 |
2013 |
|
Childhood Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The test evaluates the expression of 20 genes, including 17 markers relevant to T-cell immunology and lymphoma biopathology, one EBV-related transcript, and variants of RHOA (G17V) and IDH2 (R172K/T).
|
31488561 |
2019 |
|
Carcinogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The R132H and R172K mutations of isocitrate dehydrogenase 1 and 2, respectively, (IDH1 and IDH2) have neomorphic activity of generating 2-hydroxyglutarate (2-HG) which has been implicated in oncogenesis.
|
25251602 |
2015 |
|
Glioblastoma Multiforme
|
|
0.010 |
GeneticVariation
|
BEFREE |
Overexpression of IDH1(R132H) and IDH2(R172K) mutant protein in glioblastoma cells resulted in increased radiation sensitivity and altered ROS metabolism and suppression of growth and migration in vitro.
|
23115158 |
2013 |
|
Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The test evaluates the expression of 20 genes, including 17 markers relevant to T-cell immunology and lymphoma biopathology, one EBV-related transcript, and variants of RHOA (G17V) and IDH2 (R172K/T).
|
31488561 |
2019 |
|
Childhood Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A c.515G>T (p.R172M) mutation of the IDH2 gene was only identified in a grade II oligodendroglioma patient which was wild-type for IDH1.
|
21643842 |
2011 |
|
Anaplastic Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The R132H IDH1 mutation was identified in 43/117 tumor samples and R172K IDH2 mutation was detected in only one anaplastic oligodendroglioma.
|
27268645 |
2016 |
|
Adult Oligodendroglioma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A c.515G>T (p.R172M) mutation of the IDH2 gene was only identified in a grade II oligodendroglioma patient which was wild-type for IDH1.
|
21643842 |
2011 |
|
Leukemia, Myelocytic, Acute
|
|
0.720 |
CausalMutation
|
CLINVAR |
Impact of genetic features on treatment decisions in AML.
|
22160010 |
2011 |