|
Pancreatitis, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Screening of R122H and N29I mutations in the PRSS1 gene and N34S mutation in the SPINK1 gene in Mexican pediatric patients with acute and recurrent pancreatitis.
|
22699143 |
2012 |
|
Pancreatitis, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The prevalence of the SPINK-1/N34S mutation in patients with CP is 5.4%, and is approximately 37.1% in patients with IP.
|
21375584 |
2011 |
|
Pancreatitis, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Approximately 15-40% of patients with so-called idiopathic CP carry p.N34S on one allele or on both alleles.
|
21525753 |
2010 |
|
Pancreatitis, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The two individuals with the N34S mutation did not have any signs of chronic pancreatitis.
|
17613931 |
2007 |
|
Pancreatitis, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
PRSS1 mutations were identified mainly in CP patients (9.6% of CP vs 2.5% of ARP alleles, P = 0.094), whereas N34S SPINK1 mutation was present with comparable frequency in CP and ARP patients (7.7% vs 10.0%, P = 0.768).
|
16954950 |
2006 |
|
Pancreatitis, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
To our knowledge, this is the first reported case of chronic pancreatitis accompanied by pancreatic cancer in a patient with the SPINK1 N34S mutation.
|
15084977 |
2004 |
|
Pancreatitis, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because the SPINK1 N34S mutation is very common in the general population, it is unlikely that this mutation alone can initiate the development of chronic pancreatitis.
|
15528018 |
2004 |
|
Pancreatitis, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequencies of the promotor polymorphisms of IL10-627A, IL10-1117A, TNF-238A and TNF-308A in patients with alcoholic chronic pancreatitis, idiopathic pancreatitis, SPINK1-N34S-associated chronic pancreatitis and pancreatic cancer did not differ significantly from the control group.
|
14560157 |
2003 |
|
Pancreatitis, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a point mutation (N34S) in the gene encoding the serine protease inhibitor, Kazal type 1 (SPINK1), was found in approximately 20% of patients with CP.
|
12014716 |
2002 |
|
Pancreatitis, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggested that the -215G>A alteration, as well as the N34S alteration, is a predisposing factor for CP.
|
11355022 |
2001 |