|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
In recent years a single nucleotide polymorphism, interferon-induced transmembrane protein 3 (IFITM3) rs12252, has been shown to alter the severity of influenza infection in Asian populations.
|
30987701 |
2019 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes.
|
29202190 |
2018 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
For each sample <i>IFITM3</i> rs12252 genotype was determined and antibody levels in response to pdmH1N1, H3N2 and Influenza B infection were measured for each time point.
|
29868492 |
2018 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
Neither rs12252 nor rs8072510 showed an association according to the presence of clinical risk factors for influenza complications (P > 0.05), suggesting that these factors did not modify associations between the SNPs and hospitalized influenza.
|
29053189 |
2018 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here strong association between rs12252 and influenza was found in all four genetic models.
|
30421689 |
2018 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results indicated increased risk of both severe and mild influenza in subjects carrying the IFITM3 rs12252 polymorphism in the allele contrast C vs. T: OR (severe) = 1.69, 95% CI = 1.23-2.33, P = 0.001, and OR (mild) = 1.46, 95% CI = 1.13-1.87, P = 0.004.
|
29940276 |
2018 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
<b>Conclusion:</b><i>IFITM3</i> rs12252</span> CC genotype was associated with severity rather than susceptibility of IVI in Chinese population, and this strong effect was observed in all subtypes of seasonal influenza infection.
|
28713779 |
2017 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies have reported associations of IFITM3 SNP rs12252 with severe influenza, but evidence of association and the mechanism by which risk is conferred remain controversial.
|
28714988 |
2017 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs12252 was not associated with susceptibility to influenza-related critical illness in children or with critical illness severity.
|
28531322 |
2017 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection.
|
27351739 |
2016 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
The only Spanish patient homozygous for rs12252-C had a neurological disorder (a known risk factor for severe IVI) and mild influenza.
|
27492307 |
2016 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggests that IFITM3 rs12252 T>C polymorphism is significantly associated with increased risk of severe influenza but not with the chance of initial virus infection.
|
25778715 |
2015 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single-nucleotide polymorphism rs12252-C, which is rare in Caucasian populations, but much more common in the Han Chinese population, has been found in much higher homozygous frequency in patients with severe acute influenza.
|
25784441 |
2015 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggests a significant association between a minor IFITM3 allele (SNP rs12252-C) with severe influenza</span> susceptibility, but not in mild influenza subjects, in both UK Caucasians and Han Chinese population.
|
25942469 |
2015 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection.
|
23997235 |
2014 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
They also suggested that mechanisms, other than viral entry restriction, might contribute to variations in clinical outcomes of H1N1 influenza associated with rs12252-C.
|
25314048 |
2014 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals.
|
23361009 |
2013 |
|
Influenza
|
|
0.100 |
GeneticVariation
|
BEFREE |
We find that a statistically significant number of hospitalized subjects show enrichment for a minor IFITM3 allele (SNP rs12252-C) that alters a splice acceptor site, and functional assays show the minor CC genotype IFITM3 has reduced influenza virus restriction in vitro.
|
22446628 |
2012 |