|
Gestational Diabetes
|
|
0.070 |
GeneticVariation
|
BEFREE |
Relationship of lactation, BMI, and rs12255372 TCF7L2 polymorphism on the conversion to type 2 diabetes mellitus in women with previous gestational diabetes.
|
30614312 |
2019 |
|
Gestational Diabetes
|
|
0.070 |
GeneticVariation
|
BEFREE |
Six of eight SNPs were found to have significant associations between TCF7L2 variants and GDM risk in the overall population, with the most powerful in SNPs being rs7903146, rs12255372 and rs7901695, but the contribution of these SNPs to GDM risk were variable among different racial/ethnic groups.
|
28002648 |
2017 |
|
Gestational Diabetes
|
|
0.070 |
GeneticVariation
|
BEFREE |
In the healthy and GDM pregnant women groups, the A-allele frequencies (95% CI) of FTO polymorphisms rs8050136 and rs9939609 were 39% (34-44%); 38% (33-43%) and 40% (35-45%); 41% (36-46%), respectively; and the T-allele frequencies of TCF7L2 polymorphisms rs12255372 and rs7903146 were 30% (26-35%), 32% (27-37%) and 29% (25-34%), 36% (31-41%), respectively.
|
26102344 |
2015 |
|
Gestational Diabetes
|
|
0.070 |
GeneticVariation
|
BEFREE |
To investigate the association between fat mass and obesity-associated (FTO) gene polymorphisms rs8050136C>A and rs9939609T>A, and transcription factor 7-like 2 (TCF7L2) gene polymorphisms rs12255372G>T and rs7903146C>T, in a sample group of pregnant Euro-Brazilian women with or without gestational diabetes mellitus (GDM).
|
26102344 |
2015 |
|
Gestational Diabetes
|
|
0.070 |
GeneticVariation
|
BEFREE |
The low β-cell function, high pre-gestational BMI and rs12255372 risk allele are risk factors independently associated with the development of gestational diabetes.
|
24639413 |
2014 |
|
Gestational Diabetes
|
|
0.070 |
GeneticVariation
|
BEFREE |
Among them, genetic variants in TCF7L2 showed the strongest association with GDM risk, with ORs (95% CIs) of 1.44 (1.29-1.60, P < 0.001) per T allele of rs7903146 and 1.46 (1.15-1.84, P = 0.002) per T allele of rs12255372.
|
23690305 |
2013 |
|
Gestational Diabetes
|
|
0.070 |
GeneticVariation
|
BEFREE |
The heterozygous genotypes CT, GT and TC of the rs7903146 (T is risk for Type 2 diabetes), rs12255372 (T is risk for Type 2 diabetes) and rs7901695 (C is risk for Type 2 diabetes), respectively, as well as the homozygous genotypes TT, TT and CC of the rs7903146, rs12255372 and rs7901695, respectively, were strongly associated with gestational diabetes (P < 0.0001).
|
21672010 |
2011 |
|
Gestational Diabetes
|
|
0.070 |
GeneticVariation
|
BEFREE |
This interaction was not associated with acute insulin response to intravenous glucose. rs12255372 also showed an association with beta-cell compensation for insulin resistance based on 30' Deltainsulin in an interaction with percentage of body fat (Bonferroni-corrected P = 0.014). rs12255372 was also associated with GDM (odds ratio [OR] 2.49 [95% CI 1.17-5.31]; P = 0.018) in our case-control sample.
|
17317761 |
2007 |