rs1229984, ADH1B

N. diseases: 83
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Esophageal Neoplasms
CUI: C0014859
Disease: Esophageal Neoplasms
0.840 GeneticVariation BEFREE Our results suggested that ADH1B gene Arg47His variant was associated with the decreased esophageal cancer risk. 27450204 2016
Esophageal Neoplasms
CUI: C0014859
Disease: Esophageal Neoplasms
0.840 GeneticVariation BEFREE The functional polymorphisms ADH1B rs1229984 may contribute to susceptibility to esophageal cancer. 24093763 2014
Esophageal Neoplasms
CUI: C0014859
Disease: Esophageal Neoplasms
0.840 GeneticVariation BEFREE In conclusion, our findings indicated that ADH1B (rs1229984) was associated with EC independent of alcohol drinking and tobacco smoking status and alcohol drinking interacted with ALDH2 (rs671) on EC susceptibility in this high-risk Chinese population. 22930414 2013
Esophageal Neoplasms
CUI: C0014859
Disease: Esophageal Neoplasms
0.840 GeneticVariation GWASDB Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. 20833657 2010
Esophageal Neoplasms
CUI: C0014859
Disease: Esophageal Neoplasms
0.840 GeneticVariation BEFREE ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis. 21048924 2010
Esophageal Neoplasms
CUI: C0014859
Disease: Esophageal Neoplasms
0.840 GeneticVariation GWASCAT Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. 19698717 2009