|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation
|
BEFREE |
A pooled analysis revealed the association of rs1234314 and rs12039904 polymorphisms with SSc (OR 1.15, 95% CI 1.02 to 1.31; OR 1.18, 95% CI 1.08 to 1.29, respectively).
|
21187296 |
2011 |
|
Systemic Scleroderma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Case-control comparisons revealed a significant association between susceptibility to SSc and the minor alleles at SNPs rs1234314 (OR 1.20, 95% CI 1.04 to 1.4, p(FDR)=0.019), rs2205960 (OR 1.24, 95% CI 1.10 to 1.50, p(FDR)=0.019) and rs844648 (OR 1.16, 95% CI 1.01 to 1.30, p(FDR)=0.032).
|
19778912 |
2010 |
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we stratified eligible studies by type of disease, positive results were observed for rs17568 variant in subjects with acute coronary syndrome (ACS) (allele model: P = 0.04, OR = 0.81, 95%CI, 0.65-0.99), for rs1234314 variant in subjects with coronary artery disease (CAD) (dominant model: P = 0.04, OR = 1.16, 95%CI, 1.00-1.35), for rs3850641 variant in subjects with CAD (recessive model: P = 0.02, OR = 1.42, 95%CI, 1.05-1.90) and myocardial infarction (MI) (recessive model: P = 0.03, OR = 1.49, 95%CI, 1.05-2.11).
|
30614039 |
2019 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we stratified eligible studies by type of disease, positive results were observed for rs17568 variant in subjects with acute coronary syndrome (ACS) (allele model: P = 0.04, OR = 0.81, 95%CI, 0.65-0.99), for rs1234314 variant in subjects with coronary artery disease (CAD) (dominant model: P = 0.04, OR = 1.16, 95%CI, 1.00-1.35), for rs3850641 variant in subjects with CAD (recessive model: P = 0.02, OR = 1.42, 95%CI, 1.05-1.90) and myocardial infarction (MI) (recessive model: P = 0.03, OR = 1.49, 95%CI, 1.05-2.11).
|
30614039 |
2019 |
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we stratified eligible studies by type of disease, positive results were observed for rs17568 variant in subjects with acute coronary syndrome (ACS) (allele model: P = 0.04, OR = 0.81, 95%CI, 0.65-0.99), for rs1234314 variant in subjects with coronary artery disease (CAD) (dominant model: P = 0.04, OR = 1.16, 95%CI, 1.00-1.35), for rs3850641 variant in subjects with CAD (recessive model: P = 0.02, OR = 1.42, 95%CI, 1.05-1.90) and myocardial infarction (MI) (recessive model: P = 0.03, OR = 1.49, 95%CI, 1.05-2.11).
|
30614039 |
2019 |
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we stratified eligible studies by type of disease, positive results were observed for rs17568 variant in subjects with acute coronary syndrome (ACS) (allele model: P = 0.04, OR = 0.81, 95%CI, 0.65-0.99), for rs1234314 variant in subjects with coronary artery disease (CAD) (dominant model: P = 0.04, OR = 1.16, 95%CI, 1.00-1.35), for rs3850641 variant in subjects with CAD (recessive model: P = 0.02, OR = 1.42, 95%CI, 1.05-1.90) and myocardial infarction (MI) (recessive model: P = 0.03, OR = 1.49, 95%CI, 1.05-2.11).
|
30614039 |
2019 |
|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CC (rs1234314, rs1234315) and AA (rs1600249, rs13277113) genotypes provided protective effects against AR, whereas the AG (rs13277113) genotype presented a risk factor for AR.
|
28713926 |
2017 |
|
Lymphopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our research suggests association of rs2205960-T with SLE across multiple groups and an independent non-risk signal at rs1234314-C. rs2205960-T is associated with autoantibody production and lymphopenia.
|
23874208 |
2013 |