|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Our current meta-analysis involving the rs12456492(A/G) variant demonstrated that the GG + GA genotypes, GG genotypes, and G allele may be risk factors for PD.
|
31818509 |
2020 |
|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
In the study reported here, we investigated the association of the rs12456492 and rs16976358 SNPs of the RIT2 gene with PD, essential tremor (ET), autism, schizophrenia (SCZ), and bipolar disorder (BPD; total of 2290 patients), and 1000 controls, by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
|
26941103 |
2017 |
|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Therefore, more replication studies in additional Chinese population and other cohorts are warranted to further clarify the role of RIT2 rs12456492 in PD susceptibility.
|
27889863 |
2017 |
|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
GWASCAT |
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci.
|
28892059 |
2017 |
|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
This study replicates the association between rs12456492 variant and risk of developing PD in a Han Chinese population.
|
25559334 |
2015 |
|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Our data support that the carriage of G allele of rs12456492 variant of RIT2 gene significantly increases the risk for PD in Han Chinese population, suggesting a potential role of RIT2 in the etiology of PD.
|
25457028 |
2015 |
|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
RIT2 rs12456492 polymorphism and the risk of Parkinson's disease: A meta-analysis.
|
26188085 |
2015 |
|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The current meta-analysis suggested that rs12456492</span> might be associated with increased PD risk in Asian populations, but studies using larger sample sizes and different ethnic populations will be needed to further confirm this association.
|
26334395 |
2015 |
|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
|
25064009 |
2014 |
|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
We failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for PD in our population.
|
23635658 |
2013 |
|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
GWASDB |
A novel PD susceptibility locus, RIT2, on chromosome 18 (rs12456492; p=5×10(-5) Discovery Sample; p=1.52×10(-7) Replication sample; p=2×10(-10) Combined Sample) was replicated.
|
22451204 |
2012 |
|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
A novel PD susceptibility locus, RIT2, on chromosome 18 (rs12456492; p=5×10(-5) Discovery Sample; p=1.52×10(-7) Replication sample; p=2×10(-10) Combined Sample) was replicated.
|
22451204 |
2012 |
|
Parkinson Disease
|
|
0.890 |
GeneticVariation
|
GWASCAT |
A novel PD susceptibility locus, RIT2, on chromosome 18 (rs12456492; p=5×10(-5) Discovery Sample; p=1.52×10(-7) Replication sample; p=2×10(-10) Combined Sample) was replicated.
|
22451204 |
2012 |