Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the 19 CRP-associated SNPs, rs1260326 and rs6734238 were significantly associated with CRC risk (P = 7.5 × 10-4, and P = 0.003, respectively).
|
30476131 |
2019 |
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
With respect to gene-gene interactions, the pairwise interactions of rs112129861 (PDZK1) and rs7193778 (IGF1R); rs17050272 (INHBB) and rs1106766 (R3HDM2); rs1106766 (R3HDM2) and rs780093 (GCKR); rs1260326 (GCKR) and rs17786744 (STC1); and rs17786744 (STC1) and rs1106766 (R3HDM2) make it possible to visualize the synergistic or antagonistic effect of their genotypes or alleles on KOA development.
|
29855200 |
2019 |
Nonalcoholic Steatohepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The GCKR rs1260326 and rs780094 allele T were associated with susceptibility to NAFLD (OR 1.49, 95 % CI 1.09-2.05, p = 0.012; and OR 1.51, 95 % CI 1.09-2.09, p = 0.013, respectively), non-alcoholic steatohepatitis (NASH) (OR 1.55, 95 % CI 1.10-2.17, p = 0.013; and OR 1.56, 95 % CI 1.10-2.20, p = 0.012, respectively) and NASH with significant fibrosis (OR 1.50, 95 % CI 1.01-2.21, p = 0.044; and OR 1.52, 95 % CI 1.03-2.26, p = 0.038, respectively).
|
23800943 |
2014 |
Monogenic diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
The study group included 129 children with GCK-MODY from the Polish Registry of Monogenic Diabetes and 395 with type 1 diabetes (T1DM), in whom we genotyped 2 SNPs in G6PC2 (rs560887) and GCKR (rs1260326).
|
24918535 |
2014 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The study group included 129 children with GCK-MODY from the Polish Registry of Monogenic Diabetes and 395 with type 1 diabetes (T1DM), in whom we genotyped 2 SNPs in G6PC2 (rs560887) and GCKR (rs1260326).
|
24918535 |
2014 |
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
The intronic single-nucleotide polymorphism (SNP) rs780094 (intron 16) and the missense SNP rs1260326 (P446L) in the GCKR gene are strongly associated with increased circulating triglyceride and C-reactive protein levels and, paradoxically, reductions in diabetes incidence, fasting glucose levels, and insulin resistance.
|
21525158 |
2011 |
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the general population, both TRIB1-rs2954029 and GCKR-rs1260326 were associated with lipid levels, whereas TRIB1 was also associated with increased risk of IHD and MI.
|
21071687 |
2011 |
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the general population, both TRIB1-rs2954029 and GCKR-rs1260326 were associated with lipid levels, whereas TRIB1 was also associated with increased risk of IHD and MI.
|
21071687 |
2011 |
Hyperglycemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, an additive effect of GCKR rs1260326(T) and GCK (-30G) alleles conferred lower fasting glycemia (P = 1 x 10(-13)), insulinemia (P = 5 x 10(-6)), and hyperglycemia risk (P = 1 x 10(-6)).
|
18556336 |
2008 |
Fatty Liver
|
|
0.020 |
GeneticVariation
|
BEFREE |
Metabolic effects of LYPLAL1 rs12137855-C were similar, but statistically less robust, to the effects of GCKR rs1260326-T. TM6SF2 rs58542926-T displayed opposite metabolic effects when compared with the fatty liver associations.
|
29648650 |
2018 |
Gestational Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
No associations between FTO rs9939609 and rs8050136, GCKR rs1260326 and GDM risk were found.
|
30074065 |
2018 |
Gestational Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
Several variants <i>PPARG2</i> rs1801282 (<i>C>G</i>); <i>PPARGC1A</i> rs8192678 (<i>C>T</i>); <i>TCF7L2</i> rs7903146 (<i>C>T</i>); <i>LDLR</i> rs2228671 (<i>C>T</i>); <i>MTHFR</i> rs1801133 (<i>C>T</i>); <i>APOA5</i> rs662799 (<i>T>C</i>); <i>GCKR</i> rs1260326 (<i>C>T</i>); <i>FTO</i> rs9939609 (<i>T>A</i>); <i>MC4R</i> rs17782313 (<i>T>C</i>) were genotyped in 168 pregnant Caucasian women with or without GDM by High Resolution Melting (HRM) analysis.
|
28133617 |
2017 |
Fatty Liver Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study suggests that risk allele T of the GCKR rs780094 and rs1260326 is associated with predisposition to NAFLD and NASH with significant fibrosis.
|
23800943 |
2014 |
Fatty Liver Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1).
|
23275357 |
2013 |
Fatty Liver
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs1260326 was associated with elevated triglycerides (Caucasians P = 0.00014; African Americans P = 0.00417), large very low-density lipoprotein (VLDL) (Caucasians P = 0.001; African Americans, P = 0.03), and with fatty liver (Caucasians P = 0.034; African Americans P = 0.00002; and Hispanics P = 0.016).
|
22105854 |
2012 |
Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
Here we show that adiposity significantly amplifies the effect of three sequence variants (encoding PNPLA3 p.I148M, TM6SF2 p.E167K, and GCKR p.P446L) associated with nonalcoholic fatty liver disease (NAFLD).
|
28436986 |
2017 |
Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
We investigated whether a 1-year intensive lifestyle intervention (ILI) for weight loss would avert the unfavorable cardiometabolic effects associated with GCKR Leu446Pro when compared with a diabetes mellitus support and education arm in overweight/obese individuals with type 2 diabetes mellitus with triglyceride (n=3214) and CRP (n=1411) data participating in a randomized lifestyle intervention study for weight loss, Action for Health in Diabetes Mellitus (Look AHEAD).
|
26578543 |
2016 |
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
We investigated whether a 1-year intensive lifestyle intervention (ILI) for weight loss would avert the unfavorable cardiometabolic effects associated with GCKR Leu446Pro when compared with a diabetes mellitus support and education arm in overweight/obese individuals with type 2 diabetes mellitus with triglyceride (n=3214) and CRP (n=1411) data participating in a randomized lifestyle intervention study for weight loss, Action for Health in Diabetes Mellitus (Look AHEAD).
|
26578543 |
2016 |
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
Five gout susceptibility loci were identified at the genome-wide significance level (p<5.0×10(-8)), which contained well-known urate transporter genes (ABCG2 and SLC2A9) and additional genes: rs1260326 (p=1.9×10(-12); OR=1.36) of GCKR (a gene for glucose and lipid metabolism), rs2188380 (p=1.6×10(-23); OR=1.75) of MYL2-CUX2 (genes associated with cholesterol and diabetes mellitus) and rs4073582 (p=6.4×10(-9); OR=1.66) of CNIH-2 (a gene for regulation of glutamate signalling).
|
25646370 |
2016 |
Dyslipidemias
|
|
0.030 |
GeneticVariation
|
BEFREE |
There were significant associations between rs1260333 (OR is 0.82, 95 % CI 0.74-0.92, p ~ 3.96 × 10(-4)), rs1260326 (OR is 0.82, 95 % CI 0.74-0.92, p ~ 5.31 × 10(-4)), and rs964184 (OR is 1.36, 95 % CI 1.20-1.55, p ~ 1.89 × 10(-6)) and dyslipidemia.
|
23832694 |
2013 |
Diabetes Mellitus
|
|
0.030 |
GeneticVariation
|
BEFREE |
The intronic single-nucleotide polymorphism (SNP) rs780094 (intron 16) and the missense SNP rs1260326 (P446L) in the GCKR gene are strongly associated with increased circulating triglyceride and C-reactive protein levels and, paradoxically, reductions in diabetes incidence, fasting glucose levels, and insulin resistance.
|
21525158 |
2011 |
Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
Results of logistic regression revealed that, despite higher triglyceride levels, the carriers of the GCKR variants were more protected against the development of obesity; the adjusted models confirmed the lower risk of obesity for both variants (rs1260326: OR, 0.46; 95% CI, 0.25-0.83; rs780094: OR, 0.41; 95% CI, 0.23-0.74).
|
21511510 |
2011 |
Dyslipidemias
|
|
0.030 |
GeneticVariation
|
BEFREE |
We evaluated, in a general French population, the contribution of the GCKR rs1260326-P446L polymorphism to quantitative metabolic parameters and to dyslipidemia and hyperglycemia risk.
|
18556336 |
2008 |
Dyslipidemias
|
|
0.030 |
GeneticVariation
|
BEFREE |
A polymorphism in the GCKR gene predicted dyslipidaemia (rs1260326, OR 1.15, 95% CI 1.09-1.22, p < 0.00001) but not the metabolic syndrome.
|
18853134 |
2008 |
Steatohepatitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Metabolic effects of LYPLAL1 rs12137855-C were similar, but statistically less robust, to the effects of GCKR rs1260326-T. TM6SF2 rs58542926-T displayed opposite metabolic effects when compared with the fatty liver associations.
|
29648650 |
2018 |