Hypertriglyceridemia
|
|
0.820 |
GeneticVariation
|
BEFREE |
Recently, the single nucleotide polymorphism (SNP) identified as rs1260326, in the glucokinase regulatory protein (GCKR), was associated with hypertriglyceridemia in adults.
|
22105854 |
2012 |
Hypertriglyceridemia
|
|
0.820 |
GeneticVariation
|
BEFREE |
Once demographics, medication use and baseline adiposity, and fitness were accounted for, ILI did not modify the baseline association of GCKR-Leu446Pro with elevated triglycerides (β±SE=0.067±0.013, P=1.5×10(-7) and β±SE=0.052±0.015, P=5×10(-4)) or with elevated CRP (β±SE=0.136±0.034, P=5.1×10(-5)and β±SE=0.903±0.038, P=0.015) in the overall sample and Non-Hispanic Whites, respectively.
|
26578543 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.
|
18556336 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
We investigated whether a 1-year intensive lifestyle intervention (ILI) for weight loss would avert the unfavorable cardiometabolic effects associated with GCKR Leu446Pro when compared with a diabetes mellitus support and education arm in overweight/obese individuals with type 2 diabetes mellitus with triglyceride (n=3214) and CRP (n=1411) data participating in a randomized lifestyle intervention study for weight loss, Action for Health in Diabetes Mellitus (Look AHEAD).
|
26578543 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
These findings illustrate that common gene variants, such as rs1260326, can have substantial effect sizes when they are studied in specific populations, such as type 2 diabetes.
|
27660121 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
This study shows that in patients with type 2 diabetes who were not selected for liver abnormalities, liver fat content was related to GCKR rs1260326 polymorphism independent of BMI, triglyceride levels, and age.
|
25976242 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
TWAS found locus chr2q23.3 (rs1260326) was highly pleiotropic among RHR, cardiometabolic traits, and T2D, and identified 7 genes (SMARCAD1, RP11-53O19.3, CTC-498M16.4, PDE8B, AKTIP, KDM4B, and TSHZ3) that were statistically independent and shared between RHR and T2D in tissues from the nervous and cardiovascular systems.
|
31648709 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes.
|
21511510 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.
|
22038520 |
2012 |
Non-alcoholic Fatty Liver Disease
|
|
0.760 |
GeneticVariation
|
BEFREE |
This study suggests that risk allele T of the GCKR rs780094 and rs1260326 is associated with predisposition to NAFLD and NASH with significant fibrosis.
|
23800943 |
2014 |
Non-alcoholic Fatty Liver Disease
|
|
0.760 |
GeneticVariation
|
BEFREE |
Additionally, our results suggest Asian-specific, liver biopsy-specific, adult-specific and pediatric-specific associations between the rs1260326 and NAFLD.
|
30646922 |
2019 |
Non-alcoholic Fatty Liver Disease
|
|
0.760 |
GeneticVariation
|
BEFREE |
Our results show that GCKR rs1260326 T-allele is associated with better response of NAFLD patients to nutritional treatment regarding fasting blood glucose, but not oxLDL levels.
|
28695325 |
2018 |
Non-alcoholic Fatty Liver Disease
|
|
0.760 |
GeneticVariation
|
BEFREE |
Among the eleven genotyped SNPs, the genetic variants in TM6SF2 rs58542926 (OR = 4.13, p = 0.002), GCKR rs1260326 (OR = 1.53, p = 0.003), PNPLA3 rs738409 (OR = 1.58, p = 0.004) and ELOVL2 rs2236212 (OR = 1.34, p = 0.047) were significantly associated with a higher risk of NAFLD.
|
31255630 |
2019 |
Non-alcoholic Fatty Liver Disease
|
|
0.760 |
GeneticVariation
|
BEFREE |
Among individual variants, rs1260326 in GCKR and rs641738 in MBOAT7 (recessive), rs58542926 in TM6SF2 and rs738409 in PNPLA3 (dominant) emerged as associated to NAFLD, with PNPLA3 rs738409 being the strongest predictor (OR 3.12, 95% CI, 1.8-5.5, P < 0.001).
|
29487372 |
2018 |
Non-alcoholic Fatty Liver Disease
|
|
0.760 |
GeneticVariation
|
BEFREE |
Here we show that adiposity significantly amplifies the effect of three sequence variants (encoding PNPLA3 p.I148M, TM6SF2 p.E167K, and GCKR p.P446L) associated with nonalcoholic fatty liver disease (NAFLD).
|
28436986 |
2017 |
Chronic Kidney Diseases
|
|
0.710 |
GeneticVariation
|
BEFREE |
The present study suggests a possible association of the T/T genotype of GCKR rs1260326 polymorphism with elevated risk of CKD and its interaction with current smoking, which may support the possibility of performing risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.
|
24535998 |
2014 |
Steatohepatitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs1260326 was associated with elevated triglycerides (Caucasians P = 0.00014; African Americans P = 0.00417), large very low-density lipoprotein (VLDL) (Caucasians P = 0.001; African Americans, P = 0.03), and with fatty liver (Caucasians P = 0.034; African Americans P = 0.00002; and Hispanics P = 0.016).
|
22105854 |
2012 |
Steatohepatitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Histological data showed significant association of GCKR rs1260326 with high steatosis grade (OR 1.76, 95 % CI 1.08-2.85, p = 0.04).
|
23800943 |
2014 |
Metabolic Syndrome X
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our aim was to investigate: i) the relationship between the GCKR rs1260326 (Pro446Leu) polymorphism and parameters of the MetS; and ii) a potential influence of n-3 and n-6 LC-PUFA levels on this relationship in the HELENA study (1,155 European adolescents).
|
26136510 |
2015 |
Steatohepatitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Metabolic effects of LYPLAL1 rs12137855-C were similar, but statistically less robust, to the effects of GCKR rs1260326-T. TM6SF2 rs58542926-T displayed opposite metabolic effects when compared with the fatty liver associations.
|
29648650 |
2018 |
Metabolic Syndrome X
|
|
0.040 |
GeneticVariation
|
BEFREE |
A polymorphism in the GCKR gene predicted dyslipidaemia (rs1260326, OR 1.15, 95% CI 1.09-1.22, p < 0.00001) but not the metabolic syndrome.
|
18853134 |
2008 |
Steatohepatitis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1).
|
23275357 |
2013 |
Metabolic Syndrome X
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations.
|
21114848 |
2010 |
Metabolic Syndrome X
|
|
0.040 |
GeneticVariation
|
BEFREE |
We have demonstrated a significant interaction between the GCKR rs1260326-P446L polymorphism and plasma n-3 PUFA levels modulating insulin resistance and inflammatory markers in MetS subjects.
|
21674002 |
2011 |
Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
We investigated whether a 1-year intensive lifestyle intervention (ILI) for weight loss would avert the unfavorable cardiometabolic effects associated with GCKR Leu446Pro when compared with a diabetes mellitus support and education arm in overweight/obese individuals with type 2 diabetes mellitus with triglyceride (n=3214) and CRP (n=1411) data participating in a randomized lifestyle intervention study for weight loss, Action for Health in Diabetes Mellitus (Look AHEAD).
|
26578543 |
2016 |