rs1260326, GCKR

N. diseases: 81
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
FASTING PLASMA GLUCOSE LEVEL QUANTITATIVE TRAIT LOCUS 5
0.700 GeneticVariation CLINVAR
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Common genetic variation near MC4R is associated with waist circumference and insulin resistance. 18454146 2008
High density lipoprotein measurement
0.700 GeneticVariation GWASDB Common genetic variation near MC4R is associated with waist circumference and insulin resistance. 18454146 2008
Diabetes Mellitus, Non-Insulin-Dependent
0.770 GeneticVariation BEFREE The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. 18556336 2008
Dyslipidemias
CUI: C0242339
Disease: Dyslipidemias
0.030 GeneticVariation BEFREE We evaluated, in a general French population, the contribution of the GCKR rs1260326-P446L polymorphism to quantitative metabolic parameters and to dyslipidemia and hyperglycemia risk. 18556336 2008
Hyperglycemia
CUI: C0020456
Disease: Hyperglycemia
0.010 GeneticVariation BEFREE Moreover, an additive effect of GCKR rs1260326(T) and GCK (-30G) alleles conferred lower fasting glycemia (P = 1 x 10(-13)), insulinemia (P = 5 x 10(-6)), and hyperglycemia risk (P = 1 x 10(-6)). 18556336 2008
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.040 GeneticVariation BEFREE A polymorphism in the GCKR gene predicted dyslipidaemia (rs1260326, OR 1.15, 95% CI 1.09-1.22, p < 0.00001) but not the metabolic syndrome. 18853134 2008
Dyslipidemias
CUI: C0242339
Disease: Dyslipidemias
0.030 GeneticVariation BEFREE A polymorphism in the GCKR gene predicted dyslipidaemia (rs1260326, OR 1.15, 95% CI 1.09-1.22, p < 0.00001) but not the metabolic syndrome. 18853134 2008
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Common variants at 30 loci contribute to polygenic dyslipidemia. 19060906 2009
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASDB Common variants at 30 loci contribute to polygenic dyslipidemia. 19060906 2009
elevated blood glucose level
CUI: C0495706
Disease: elevated blood glucose level
0.800 GeneticVariation GWASDB Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. 19060910 2009
Glucose measurement
CUI: C0337438
Disease: Glucose measurement
0.800 GeneticVariation GWASDB Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. 19060910 2009
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. 19060910 2009
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASDB Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. 19060911 2009
Uric acid measurement (procedure)
CUI: C0202239
Disease: Uric acid measurement (procedure)
0.800 GeneticVariation GWASDB Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. 19503597 2009
Lipids measurement
CUI: C0523744
Disease: Lipids measurement
0.700 GeneticVariation GWASCAT Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. 19936222 2009
Glucose tolerance test
CUI: C0017741
Disease: Glucose tolerance test
0.800 GeneticVariation GWASCAT Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. 20081857 2010
Glucose tolerance test
CUI: C0017741
Disease: Glucose tolerance test
0.800 GeneticVariation GWASDB Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. 20081857 2010
Triglycerides measurement
CUI: C0202236
Disease: Triglycerides measurement
0.800 GeneticVariation GWASCAT Genome-wide association study of hematological and biochemical traits in a Japanese population. 20139978 2010
Serum albumin measurement
CUI: C0523465
Disease: Serum albumin measurement
0.800 GeneticVariation GWASCAT Genome-wide association study of hematological and biochemical traits in a Japanese population. 20139978 2010
Chronic Kidney Diseases
CUI: C1561643
Disease: Chronic Kidney Diseases
0.710 GeneticVariation GWASDB New loci associated with kidney function and chronic kidney disease. 20383146 2010
Creatinine measurement, serum (procedure)
0.700 GeneticVariation GWASCAT New loci associated with kidney function and chronic kidney disease. 20383146 2010
Kidney Failure, Chronic
CUI: C0022661
Disease: Kidney Failure, Chronic
0.700 GeneticVariation GWASCAT New loci associated with kidney function and chronic kidney disease. 20383146 2010
Hypertriglyceridemia
CUI: C0020557
Disease: Hypertriglyceridemia
0.820 GeneticVariation GWASDB Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. 20657596 2010
Hypertriglyceridemia
CUI: C0020557
Disease: Hypertriglyceridemia
0.820 GeneticVariation GWASCAT Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. 20657596 2010