|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
TWAS found locus chr2q23.3 (rs1260326) was highly pleiotropic among RHR, cardiometabolic traits, and T2D, and identified 7 genes (SMARCAD1, RP11-53O19.3, CTC-498M16.4, PDE8B, AKTIP, KDM4B, and TSHZ3) that were statistically independent and shared between RHR and T2D in tissues from the nervous and cardiovascular systems.
|
31648709 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
GWASCAT |
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
|
29632382 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
We investigated whether a 1-year intensive lifestyle intervention (ILI) for weight loss would avert the unfavorable cardiometabolic effects associated with GCKR Leu446Pro when compared with a diabetes mellitus support and education arm in overweight/obese individuals with type 2 diabetes mellitus with triglyceride (n=3214) and CRP (n=1411) data participating in a randomized lifestyle intervention study for weight loss, Action for Health in Diabetes Mellitus (Look AHEAD).
|
26578543 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
These findings illustrate that common gene variants, such as rs1260326, can have substantial effect sizes when they are studied in specific populations, such as type 2 diabetes.
|
27660121 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
This study shows that in patients with type 2 diabetes who were not selected for liver abnormalities, liver fat content was related to GCKR rs1260326 polymorphism independent of BMI, triglyceride levels, and age.
|
25976242 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk.
|
22038520 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
Recently, the association of the natural variants rs1260326 and rs780094 of the glucokinase regulatory protein (GCKR) gene with increased fasting triglycerides and decreased fasting plasma glucose in diabetic adults was reported; the minor alleles were also found to reduce the risk of type 2 diabetes.
|
21511510 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.770 |
GeneticVariation
|
BEFREE |
The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.
|
18556336 |
2008 |