rs1260326, GCKR

N. diseases: 81
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.040 GeneticVariation BEFREE Our aim was to investigate: i) the relationship between the GCKR rs1260326 (Pro446Leu) polymorphism and parameters of the MetS; and ii) a potential influence of n-3 and n-6 LC-PUFA levels on this relationship in the HELENA study (1,155 European adolescents). 26136510 2015
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.040 GeneticVariation BEFREE We have demonstrated a significant interaction between the GCKR rs1260326-P446L polymorphism and plasma n-3 PUFA levels modulating insulin resistance and inflammatory markers in MetS subjects. 21674002 2011
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.040 GeneticVariation BEFREE Our results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations. 21114848 2010
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.040 GeneticVariation BEFREE A polymorphism in the GCKR gene predicted dyslipidaemia (rs1260326, OR 1.15, 95% CI 1.09-1.22, p < 0.00001) but not the metabolic syndrome. 18853134 2008