Malignant neoplasm of ovary
|
|
0.030 |
GeneticVariation
|
BEFREE |
The recessive model of ESR2 rs1271572 and the dominant model of ESR2 rs3020450 might be susceptible factors for ovarian cancer.
|
29535531 |
2018 |
Carcinoma, Ovarian Epithelial
|
|
0.030 |
GeneticVariation
|
BEFREE |
The recessive model of ESR2 rs1271572 and the dominant model of ESR2 rs3020450 might be susceptible factors for ovarian cancer.
|
29535531 |
2018 |
Malignant neoplasm of ovary
|
|
0.030 |
GeneticVariation
|
BEFREE |
This pooled analysis suggests that rs1271572 might influence the risk of ovarian cancer, in particular among younger women.
|
21673961 |
2011 |
Carcinoma, Ovarian Epithelial
|
|
0.030 |
GeneticVariation
|
BEFREE |
This pooled analysis suggests that rs1271572 might influence the risk of ovarian cancer, in particular among younger women.
|
21673961 |
2011 |
Carcinoma, Ovarian Epithelial
|
|
0.030 |
GeneticVariation
|
BEFREE |
Compared to homozygous common allele carriers, homozygous carriers of variant alleles for rs1271572 [odds ratio (OR) = 1.79, 95% confidence interval (CI):1.15-2.79, p global = 0.01] and rs1256030 [OR = 1.67, CI: 1.08-2.59, p global = 0.04], and women with haplotypes, including variant alleles of rs1271572, rs1256030, and rs1256031 SNPs [OR = 1.75, CI: 1.17-2.63, p global = 0.007], had significantly increased risk of ovarian carcinoma.
|
18704709 |
2009 |
Malignant neoplasm of ovary
|
|
0.030 |
GeneticVariation
|
BEFREE |
Compared to homozygous common allele carriers, homozygous carriers of variant alleles for rs1271572 [odds ratio (OR) = 1.79, 95% confidence interval (CI):1.15-2.79, p global = 0.01] and rs1256030 [OR = 1.67, CI: 1.08-2.59, p global = 0.04], and women with haplotypes, including variant alleles of rs1271572, rs1256030, and rs1256031 SNPs [OR = 1.75, CI: 1.17-2.63, p global = 0.007], had significantly increased risk of ovarian carcinoma.
|
18704709 |
2009 |
ovarian neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
The recessive model of ESR2 rs1271572 and the dominant model of ESR2 rs3020450 might be susceptible factors for ovarian cancer.
|
29535531 |
2018 |
ovarian neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
This pooled analysis suggests that rs1271572 might influence the risk of ovarian cancer, in particular among younger women.
|
21673961 |
2011 |
Ovarian Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium.
|
21673961 |
2011 |
Ovarian Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Compared to homozygous common allele carriers, homozygous carriers of variant alleles for rs1271572 [odds ratio (OR) = 1.79, 95% confidence interval (CI):1.15-2.79, p global = 0.01] and rs1256030 [OR = 1.67, CI: 1.08-2.59, p global = 0.04], and women with haplotypes, including variant alleles of rs1271572, rs1256030, and rs1256031 SNPs [OR = 1.75, CI: 1.17-2.63, p global = 0.007], had significantly increased risk of ovarian carcinoma.
|
18704709 |
2009 |
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs1271572 SNP T variant was associated with increased risk of MI in a Spanish population, and this association was found to be limited to men only.
|
18487282 |
2008 |
Myocardial Infarction
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conditional logistic multivariate regression, the rs1271572 variant was associated with increased odds of CVD [odds ratio (OR) = 1.49, 95% CI: 1.10-2.01] and MI (OR = 1.46, 95% CI: 0.96-2.23), whereas the rs1256049 variant was associated with decreased odds of CVD (OR = 0.37, 95% CI: 0.17-0.79) and MI (OR = 0.25, 95% CI: 0.09-0.73) in women.
|
17702854 |
2007 |
Acute myocardial infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
Women carrying a T allele at the rs1271572 locus of the ESR2 gene demonstrated an even higher risk (OR: 3.23, 95% CI: 1.55-6.73, P = 0.0019, TS vs. MI + CTRL; OR: 9.13, 95% CI: 2.78-29.9, P = 0.0001, TS vs. MI alone).
|
28118181 |
2017 |
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
TT genotype of rs1271572 is associated with increased risk for breast cancer in Chinese women and is associated with unfavored prognosis in Chinese breast cancer patients.
|
23711151 |
2013 |
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
TT genotype of rs1271572 is associated with increased risk for breast cancer in Chinese women and is associated with unfavored prognosis in Chinese breast cancer patients.
|
23711151 |
2013 |
Metastatic malignant neoplasm to brain
|
|
0.010 |
GeneticVariation
|
BEFREE |
Breast cancer patients with the TT genotype of rs1271572 had lower five-year survival rates than those with other genotypes and were more likely to suffer brain metastases.
|
23711151 |
2013 |
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
The relationship of three polymorphisms (rs1271572, rs1256049 and rs4986938) and their associated haplotypes in the ESR2 gene with obesity and overweight were evaluated in 561 apparently healthy women (median age 63 years) from the Women's Health Study.
|
19111408 |
2009 |
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conditional logistic multivariate regression, the rs1271572 variant was associated with increased odds of CVD [odds ratio (OR) = 1.49, 95% CI: 1.10-2.01] and MI (OR = 1.46, 95% CI: 0.96-2.23), whereas the rs1256049 variant was associated with decreased odds of CVD (OR = 0.37, 95% CI: 0.17-0.79) and MI (OR = 0.25, 95% CI: 0.09-0.73) in women.
|
17702854 |
2007 |
Penile hypospadias
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four haplotype-tagging single nucleotide polymorphisms (rs2987983, rs1887994, rs1256040, and rs1256062), the (CA)n polymorphism, and two additional promoter single nucleotide polymorphisms (rs10483774 and rs1271572), mapping to a transcription factor binding region, were typed and analyzed in a Swedish cohort of 354 boys with nonsyndromic hypospadias and 380 healthy controls.
|
17579196 |
2007 |
Hypospadias
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four haplotype-tagging single nucleotide polymorphisms (rs2987983, rs1887994, rs1256040, and rs1256062), the (CA)n polymorphism, and two additional promoter single nucleotide polymorphisms (rs10483774 and rs1271572), mapping to a transcription factor binding region, were typed and analyzed in a Swedish cohort of 354 boys with nonsyndromic hypospadias and 380 healthy controls.
|
17579196 |
2007 |
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
Women, but not men, who developed CVD or MI, but not ischemic stroke, were more likely to have the rs1271572 polymorphism variant T allele (P = 0.05 and 0.02) and less likely to have the rs1256049 polymorphism variant A allele (P = 0.003 and 0.004).
|
17702854 |
2007 |
Malignant neoplasm of endometrium
|
|
0.010 |
GeneticVariation
|
BEFREE |
After adjusting for potential confounders, we observed no association between ESR2 gene polymorphisms and endometrial cancer risk [rs1256049 (OR = 1.2; 95%CI: 0.7-2.3), rs1271572 (OR = 0.8; 95%CI: 0.5-1.1) and CA repeat (22 repeat allele versus > or = 22 repeat allele, OR = 1.1; 95%CI: 0.7-1.7)].
|
15280642 |
2004 |
Endometrial Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
After adjusting for potential confounders, we observed no association between ESR2 gene polymorphisms and endometrial cancer risk [rs1256049 (OR = 1.2; 95%CI: 0.7-2.3), rs1271572 (OR = 0.8; 95%CI: 0.5-1.1) and CA repeat (22 repeat allele versus > or = 22 repeat allele, OR = 1.1; 95%CI: 0.7-1.7)].
|
15280642 |
2004 |