Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE In summary, the T/T <i>genotype of MGMT</i> rs12917 is likely to be linked to an enhanced susceptibility to cancer overall, especially glioma, in the Caucasian population. 30232235 2018
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.070 GeneticVariation BEFREE In summary, the T/T <i>genotype of MGMT</i> rs12917 is likely to be linked to an enhanced susceptibility to cancer overall, especially glioma, in the Caucasian population. 30232235 2018
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE We carried out a meta-analysis of 44 case-control studies to clarify the association between the Leu84Phe polymorphism and cancer risk. 24086516 2013
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.070 GeneticVariation BEFREE Results from the current meta-analysis suggested that Leu84Phe and Ile143Val in the MGMT gene are risk factors for cancer. 23760981 2013
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE Results from the current meta-analysis suggested that Leu84Phe and Ile143Val in the MGMT gene are risk factors for cancer. 23760981 2013
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.070 GeneticVariation BEFREE We carried out a meta-analysis of 44 case-control studies to clarify the association between the Leu84Phe polymorphism and cancer risk. 24086516 2013
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.070 GeneticVariation BEFREE Its two common single-nucleotide polymorphisms, Leu84Phe and Ile143Val, had previously been identified to contribute to susceptibility of cancer. 19892775 2010
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE Its two common single-nucleotide polymorphisms, Leu84Phe and Ile143Val, had previously been identified to contribute to susceptibility of cancer. 19892775 2010
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE Several common coding-region polymorphisms in the MGMT gene (L84F and the linked pair I143V/K178R) modify functional characteristics of MGMT and cancer risk. 18812520 2009
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.070 GeneticVariation BEFREE Several common coding-region polymorphisms in the MGMT gene (L84F and the linked pair I143V/K178R) modify functional characteristics of MGMT and cancer risk. 18812520 2009
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.070 GeneticVariation BEFREE For UADT cancer risk, associations were observed for the homozygous carriers of the variant alleles of MGMT L84F [odds ratio (OR) 2.35, 95% confidence interval (CI) 1.32-4.20], MGMT 171C > T (OR 2.24, 95% CI 1.20-4.17) and OGG1 S326C (OR 2.07, 95% CI 1.15-3.73) whilst three variants were associated with a protective effect (XPA 23G > A, P for trend 0.022, APEX Q51H, P for trend 0.036, CHEK2 intron 9-200T > C, P for trend 0.009). 17040931 2007
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE For UADT cancer risk, associations were observed for the homozygous carriers of the variant alleles of MGMT L84F [odds ratio (OR) 2.35, 95% confidence interval (CI) 1.32-4.20], MGMT 171C > T (OR 2.24, 95% CI 1.20-4.17) and OGG1 S326C (OR 2.07, 95% CI 1.15-3.73) whilst three variants were associated with a protective effect (XPA 23G > A, P for trend 0.022, APEX Q51H, P for trend 0.036, CHEK2 intron 9-200T > C, P for trend 0.009). 17040931 2007
Malignant Neoplasms
CUI: C0006826
Disease: Malignant Neoplasms
0.070 GeneticVariation BEFREE DNA single-strand breaks (SSBs) were quantified by single-cell gel electrophoresis and micronucleated and apoptotic cells were quantified by microscopic assays in peripheral blood lymphocytes after irradiation on ice with 2 Gy of 60Co gamma radiation, and their association with polymorphisms of genes that encode proteins of different DNA repair pathways and influence cancer risk (XPD codon 312Asp --> Asn and 751Lys --> Gln, XRCC1 399Arg --> Gln, and MGMT 84Leu --> Phe) was studied. 16038584 2005
Primary malignant neoplasm
CUI: C1306459
Disease: Primary malignant neoplasm
0.070 GeneticVariation BEFREE DNA single-strand breaks (SSBs) were quantified by single-cell gel electrophoresis and micronucleated and apoptotic cells were quantified by microscopic assays in peripheral blood lymphocytes after irradiation on ice with 2 Gy of 60Co gamma radiation, and their association with polymorphisms of genes that encode proteins of different DNA repair pathways and influence cancer risk (XPD codon 312Asp --> Asn and 751Lys --> Gln, XRCC1 399Arg --> Gln, and MGMT 84Leu --> Phe) was studied. 16038584 2005
Glioma
CUI: C0017638
Disease: Glioma
0.040 GeneticVariation BEFREE In summary, the T/T <i>genotype of MGMT</i> rs12917 is likely to be linked to an enhanced susceptibility to cancer overall, especially glioma, in the Caucasian population. 30232235 2018
Glioma
CUI: C0017638
Disease: Glioma
0.040 GeneticVariation BEFREE This meta-analysis suggests that glioma susceptibility is associated with rs1799782 and rs25487 of X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), rs1805377 of XRCC4, rs1800067 of excision repair cross-complementing rodent repair deficiency complementation group 4 (ERCC4) and rs3212986 of ERCC1 in Asian population, and rs12917 of O-6-methylguanine-DNA methyltransferase (MGMT) and rs1136410 of poly(ADP-ribose) polymerase 1 (PARP1) in Caucasian population. 27055523 2017
Glioma
CUI: C0017638
Disease: Glioma
0.040 GeneticVariation BEFREE We found that SNPs rs3212986 (odds ratio [OR] = 1.35 (1.08-1.68), P = .008), rs13181 (OR = 1.18 (1.06-1.31), P = .002), and rs25487 (OR = 1.12 (1.03-1.22), P = .007) in DNA repair genes ERCC1, ERCC2 (XPD), and XRCC1 may increase the risk of glioma, while polymorphisms rs1136410 (OR = 0.78 (0.68-0.89), P = .0004) and rs12917 (OR = 0.84 (0.73-0.96), P = .01) in PARP1(ADPRT) and MGMT are associated with decreased susceptibility to glioma. 24500421 2014
Glioma
CUI: C0017638
Disease: Glioma
0.040 GeneticVariation BEFREE Furthermore, the multifactor dimensionality reduction and classification and regression tree analyses identified MGMT F84L as the predominant risk factor for glioma and revealed strong interactions among ionizing radiation exposure, PARP1 A762V, MGMT F84L, and APEX1 E148D. 19124499 2009
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.030 GeneticVariation BEFREE Our results showed that MGMT rs12917 and higher levels of methylation in the MGMT promoter are associated with the risk of LC. 30785779 2019
Malignant neoplasm of lung
CUI: C0242379
Disease: Malignant neoplasm of lung
0.030 GeneticVariation BEFREE Our results showed that MGMT rs12917 and higher levels of methylation in the MGMT promoter are associated with the risk of LC. 30785779 2019
Primary malignant neoplasm of lung
CUI: C1306460
Disease: Primary malignant neoplasm of lung
0.030 GeneticVariation BEFREE Our results showed that MGMT rs12917 and higher levels of methylation in the MGMT promoter are associated with the risk of LC. 30785779 2019
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.030 GeneticVariation BEFREE In conclusion, this meta-analysis suggests that the PARP-1 rs1136410: T > C polymorphism is a susceptibility factor for GI cancers, but the variant allele of MGMT rs12917: C > T polymorphism appears to be a protective factor for colorectal cancer. 24203816 2014
Carcinoma of lung
CUI: C0684249
Disease: Carcinoma of lung
0.030 GeneticVariation BEFREE This meta-analysis suggests that the MGMT Leu84Phe polymorphisms are associated with lung cancer risk among Caucasians not in Asians. 24390665 2014
Malignant neoplasm of lung
CUI: C0242379
Disease: Malignant neoplasm of lung
0.030 GeneticVariation BEFREE This meta-analysis suggests that the MGMT Leu84Phe polymorphisms are associated with lung cancer risk among Caucasians not in Asians. 24390665 2014
Malignant neoplasm of colon and/or rectum
0.030 GeneticVariation BEFREE In conclusion, this meta-analysis suggests that the PARP-1 rs1136410: T > C polymorphism is a susceptibility factor for GI cancers, but the variant allele of MGMT rs12917: C > T polymorphism appears to be a protective factor for colorectal cancer. 24203816 2014