Malignant Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
In summary, the T/T <i>genotype of MGMT</i> rs12917 is likely to be linked to an enhanced susceptibility to cancer overall, especially glioma, in the Caucasian population.
|
30232235 |
2018 |
Primary malignant neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
In summary, the T/T <i>genotype of MGMT</i> rs12917 is likely to be linked to an enhanced susceptibility to cancer overall, especially glioma, in the Caucasian population.
|
30232235 |
2018 |
Malignant Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
We carried out a meta-analysis of 44 case-control studies to clarify the association between the Leu84Phe polymorphism and cancer risk.
|
24086516 |
2013 |
Primary malignant neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
Results from the current meta-analysis suggested that Leu84Phe and Ile143Val in the MGMT gene are risk factors for cancer.
|
23760981 |
2013 |
Malignant Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
Results from the current meta-analysis suggested that Leu84Phe and Ile143Val in the MGMT gene are risk factors for cancer.
|
23760981 |
2013 |
Primary malignant neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
We carried out a meta-analysis of 44 case-control studies to clarify the association between the Leu84Phe polymorphism and cancer risk.
|
24086516 |
2013 |
Primary malignant neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
Its two common single-nucleotide polymorphisms, Leu84Phe and Ile143Val, had previously been identified to contribute to susceptibility of cancer.
|
19892775 |
2010 |
Malignant Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
Its two common single-nucleotide polymorphisms, Leu84Phe and Ile143Val, had previously been identified to contribute to susceptibility of cancer.
|
19892775 |
2010 |
Malignant Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
Several common coding-region polymorphisms in the MGMT gene (L84F and the linked pair I143V/K178R) modify functional characteristics of MGMT and cancer risk.
|
18812520 |
2009 |
Primary malignant neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
Several common coding-region polymorphisms in the MGMT gene (L84F and the linked pair I143V/K178R) modify functional characteristics of MGMT and cancer risk.
|
18812520 |
2009 |
Primary malignant neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
For UADT cancer risk, associations were observed for the homozygous carriers of the variant alleles of MGMT L84F [odds ratio (OR) 2.35, 95% confidence interval (CI) 1.32-4.20], MGMT 171C > T (OR 2.24, 95% CI 1.20-4.17) and OGG1 S326C (OR 2.07, 95% CI 1.15-3.73) whilst three variants were associated with a protective effect (XPA 23G > A, P for trend 0.022, APEX Q51H, P for trend 0.036, CHEK2 intron 9-200T > C, P for trend 0.009).
|
17040931 |
2007 |
Malignant Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
For UADT cancer risk, associations were observed for the homozygous carriers of the variant alleles of MGMT L84F [odds ratio (OR) 2.35, 95% confidence interval (CI) 1.32-4.20], MGMT 171C > T (OR 2.24, 95% CI 1.20-4.17) and OGG1 S326C (OR 2.07, 95% CI 1.15-3.73) whilst three variants were associated with a protective effect (XPA 23G > A, P for trend 0.022, APEX Q51H, P for trend 0.036, CHEK2 intron 9-200T > C, P for trend 0.009).
|
17040931 |
2007 |
Malignant Neoplasms
|
|
0.070 |
GeneticVariation
|
BEFREE |
DNA single-strand breaks (SSBs) were quantified by single-cell gel electrophoresis and micronucleated and apoptotic cells were quantified by microscopic assays in peripheral blood lymphocytes after irradiation on ice with 2 Gy of 60Co gamma radiation, and their association with polymorphisms of genes that encode proteins of different DNA repair pathways and influence cancer risk (XPD codon 312Asp --> Asn and 751Lys --> Gln, XRCC1 399Arg --> Gln, and MGMT 84Leu --> Phe) was studied.
|
16038584 |
2005 |
Primary malignant neoplasm
|
|
0.070 |
GeneticVariation
|
BEFREE |
DNA single-strand breaks (SSBs) were quantified by single-cell gel electrophoresis and micronucleated and apoptotic cells were quantified by microscopic assays in peripheral blood lymphocytes after irradiation on ice with 2 Gy of 60Co gamma radiation, and their association with polymorphisms of genes that encode proteins of different DNA repair pathways and influence cancer risk (XPD codon 312Asp --> Asn and 751Lys --> Gln, XRCC1 399Arg --> Gln, and MGMT 84Leu --> Phe) was studied.
|
16038584 |
2005 |
Glioma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In summary, the T/T <i>genotype of MGMT</i> rs12917 is likely to be linked to an enhanced susceptibility to cancer overall, especially glioma, in the Caucasian population.
|
30232235 |
2018 |
Glioma
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that glioma susceptibility is associated with rs1799782 and rs25487 of X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), rs1805377 of XRCC4, rs1800067 of excision repair cross-complementing rodent repair deficiency complementation group 4 (ERCC4) and rs3212986 of ERCC1 in Asian population, and rs12917 of O-6-methylguanine-DNA methyltransferase (MGMT) and rs1136410 of poly(ADP-ribose) polymerase 1 (PARP1) in Caucasian population.
|
27055523 |
2017 |
Glioma
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found that SNPs rs3212986 (odds ratio [OR] = 1.35 (1.08-1.68), P = .008), rs13181 (OR = 1.18 (1.06-1.31), P = .002), and rs25487 (OR = 1.12 (1.03-1.22), P = .007) in DNA repair genes ERCC1, ERCC2 (XPD), and XRCC1 may increase the risk of glioma, while polymorphisms rs1136410 (OR = 0.78 (0.68-0.89), P = .0004) and rs12917 (OR = 0.84 (0.73-0.96), P = .01) in PARP1(ADPRT) and MGMT are associated with decreased susceptibility to glioma.
|
24500421 |
2014 |
Glioma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Furthermore, the multifactor dimensionality reduction and classification and regression tree analyses identified MGMT F84L as the predominant risk factor for glioma and revealed strong interactions among ionizing radiation exposure, PARP1 A762V, MGMT F84L, and APEX1 E148D.
|
19124499 |
2009 |
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results showed that MGMT rs12917 and higher levels of methylation in the MGMT promoter are associated with the risk of LC.
|
30785779 |
2019 |
Malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results showed that MGMT rs12917 and higher levels of methylation in the MGMT promoter are associated with the risk of LC.
|
30785779 |
2019 |
Primary malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results showed that MGMT rs12917 and higher levels of methylation in the MGMT promoter are associated with the risk of LC.
|
30785779 |
2019 |
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggests that the PARP-1 rs1136410: T > C polymorphism is a susceptibility factor for GI cancers, but the variant allele of MGMT rs12917: C > T polymorphism appears to be a protective factor for colorectal cancer.
|
24203816 |
2014 |
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the MGMT Leu84Phe polymorphisms are associated with lung cancer risk among Caucasians not in Asians.
|
24390665 |
2014 |
Malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that the MGMT Leu84Phe polymorphisms are associated with lung cancer risk among Caucasians not in Asians.
|
24390665 |
2014 |
Malignant neoplasm of colon and/or rectum
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis suggests that the PARP-1 rs1136410: T > C polymorphism is a susceptibility factor for GI cancers, but the variant allele of MGMT rs12917: C > T polymorphism appears to be a protective factor for colorectal cancer.
|
24203816 |
2014 |