|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggested that FTO rs9939609, MC4R rs12970134, and MC4R rs17782313 are strongly associated with obesity.
|
30896429 |
2019 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We identified the effect of MC4R rs12970134 on overweight/obesity and BMI, and we also found physical activity and sedentary behaviors modified the association between the rs12970134 and BMI in Chinese children and adolescents.
|
28081251 |
2017 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The family-based association analysis showed that there was a significant association between rs12970134 and obesity (Z = 2.449, P = 0.014).
|
28520814 |
2017 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We did not confirm the explicit effect of rs12970134 on obesity.
|
26680479 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we examined the association between variants in fat mass- and obesity-associated [rs9939609 (A/T)], melanocortin 4 receptor [rs17782313 (C/T), and rs12970134 (A/G)], SLC30A8 [rs13266634 (C/T)], and a member of the potassium voltage-gated channels [rs2237892(C/T)] genes in diabetes patients from Saudi Arabia.
|
25501231 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD.
|
24458218 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Only the rs12970134 in the MC4R gene was significantly associated with overweight/obesity risk, with a higher frequency of the AA risk genotype in children with a BMI >85th (8.3%) than in those with a BMI <85th percentile (3.0%), p = 0.001; odds ratio (95% CI) of 1.544 (1.192-1.998), p = 0.001, after adjusting for age, sex and pubertal stage.
|
25115458 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The AA genotype of SNP rs12970134 near MC4R was associated to obesity both in CAD group and CAD-free group in Han Chinese population (P < 0.001, OR = 2.96, 95% CI 2.01-3.73; and P = 0.003, OR = 2.59, 95% CI 1.86-3.19, respectively).
|
21625854 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have shown that variants near the melanocortin 4 receptor gene (MC4R) (rs17782313 and rs12970134) are associated with risk of obesity in Europeans.
|
22869321 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genome-wide association studies on Europeans have shown that two polymorphisms (rs17782313, rs12970134) near the melanocortin 4 receptor (MC4R) gene were associated with increased risk of obesity.
|
23049848 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In sum, our data support the associations of variants rs17782313 and rs12970134 near MC4R with early onset obesity and increased insulin levels.
|
21372613 |
2011 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
SNP rs12970134 showed the lowest p-value (p = 0.004; relative risk for the obesity effect allele: 1.37); conditional analyses on this SNP revealed that 7 of 78 analyzed SNPs provided independent signals (p≤0.05).
|
21085626 |
2010 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs17782313, rs17700633, and rs12970134 near MC4R associate with measures of obesity in Danish individuals.
|
19073769 |
2009 |