|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results demonstrate that rs12979860, compared to rs8099917, may be a better predictor of response to the peg-IFN/RBV treatment among HCV/HIV-1 coinfected patients.
|
22328925 |
2012 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Donor and recipient genotypes of IL28B rs12979860C>T single nucleotide polymorphism were determined in 91 patients with HCV liver graft reinfection, 47 of whom were treated with pegylated interferon-α (PEG-IFN-α) and ribavirin.
|
21147186 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the AHC group, 31 (81.6%) rs12979860 CC carriers were infected with HCV genotype 1 or 4 vs. 32 (76.2%) among non-CC carriers (P=0.948).
|
21375685 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
We also found that the rs12979860, rs2227982 and rs36084323 polymorphisms showed no significant associations with susceptibility or spontaneous clearance of HCV in the anti-F antibody subgroup; however, the anti-F antibody positive subgroup might show an increased risk of N-SVR (all P < 0.001).
|
29399747 |
2018 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A new type III interferon, IFN lambda 4 (IFNL4), and its single-nucleotide polymorphism (SNP) ss469415590 causing a frame shift have been recently reported strongly to affect antiviral therapy for chronic hepatitis C virus (HCV) infection in African and Caucasian populations compared to previously reported IL-28B SNPs rs12979860 and rs8099917.
|
24646752 |
2014 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study revealed associations between the ICAM-1 gene marker, rs281437, and the progression of hepatic fibrosis in HCV genotype 4 and rs12979860 of the IL-28 B gene with viral clearance.
|
23137758 |
2013 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphism of the IL28B gene (rs8099917, rs12979860) and virological response of Pakistani hepatitis C virus genotype 3 patients to pegylated interferon therapy.
|
25462177 |
2015 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
TLR2 -174 del variant was associated with TLR2 expression and with specific downstream molecules that drive the expression of different interleukins; rs12979860 Il28B was important in response to interferon-treatment and in spontaneous clearance of HCV.
|
27183918 |
2016 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotype-genotype interaction between IL-28B rs12979860 and CTLA-4 rs3087243 was found to be significantly associated with increased susceptibility to HCV infection (adjusted OR=1.509, P=0.005).
|
26079279 |
2015 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
<i>IL28B</i> C/T polymorphism (rs12979860) was evaluated in circulating blood cells using a PCR-based restriction fragment length polymorphism assay.Overall <i>H. pylori</i> serology was positive in 38.1% of our HCV-infected subjects.
|
29510558 |
2018 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present study was to verify the genotype frequencies of SNPs rs8099917, rs12979860 and rs368234815 and to evaluate the association between SNPs and the outcome of HCV infection, taking into account the population ancestry.
|
26973228 |
2016 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast, rs12979860 (CC) and ss469415590 (TT/TT) genotypes were associated with higher SVR rated only in patients with HCV-1.
|
25938236 |
2015 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to characterize the genetic profile of patients with chronic hepatitis C virus (HCV) infection relative to polymorphisms rs12979860 and rs8099917 in gene IL28B and the association of those polymorphisms with the response to treatment with pegylated interferon and ribavirin, performed at a reference center in Brazilian Amazonia.
|
24678513 |
2014 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The IL28B rs12979860 CC genotype is associated with a higher prevalence of cirrhosis in HIV-HCV-coinfected patients than CT/TT genotypes, suggesting that IL28B CC carriers may experience a more rapid progression of HCV-related liver fibrosis, perhaps as result of increased liver inflammation.
|
21592993 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the rs12979860 polymorphism is associated with spontaneous clearance of HCV in HIV-1 Brazilian infected patients.
|
21790472 |
2012 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The interleukin 28B (IL28B) rs12979860 polymorphism is associated with treatment outcome in hepatitis C virus (HCV) genotype 1 and 4 patients.
|
24776764 |
2014 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients with the donor genotype rs12979860 CC had higher peak ALT and HCV RNA serum concentrations than those with CT/TT (p=0.04 and 0.06, respectively).
|
21147186 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among 632 participants with acute HCV, 35% were female, 82% were Caucasian, 49% had interleukin-28 (IL28)B CC genotype (rs12979860), 96% had injected drugs ever, 47% were infected with HCV genotype 1, and 7% had human immunodeficiency virus (HIV) coinfection.
|
23908124 |
2014 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CC genotype of IL-28B SNP rs12979860 is an independent predictive factor for SVR in chronic HCV-infected patients in Pakistan.
|
25708904 |
2015 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the association between IL28B single-nucleotide polymorphism rs12979860, hepatitis C virus (HCV) kinetic, and pegylated interferon alpha-2a pharmacodynamic parameters in HIV/HCV-coinfected patients from South America.
|
21157362 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interleukin 28B rs12979860 single-nucleotide polymorphism predicts spontaneous clearance of hepatitis C virus in children.
|
24792632 |
2014 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies have identified two host single-nucleotide polymorphisms (SNPs) near the IL28B gene (rs12979860 C/T and rs8099917 T/G) that are associated with sustained virological response in patients infected with the hepatitis C virus.
|
21704279 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
The patient had the IL-28B gene polymorphism rs12979860 CT genotype, which is associated not only with antiviral therapy response but also with diabetes risk after liver transplantation for hepatitis C.
|
25204264 |
2015 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the interaction between IL-28B rs12979860 T/T genotype and low serum cholesterol concentration is an independent predictor of a worse disease course among patients infected with HCV with normal or near-normal transaminases.
|
22431022 |
2012 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study investigated whether the IL28B SNP (rs12979860) is associated with spontaneous clearance of HCV, principally genotype 4, in 162 Egyptians (80 with clearance).
|
21933876 |
2011 |