|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
<b>Introduction:</b> IFNL4 rs12979860 genotype CC is associated with increased ALT activity and liver stiffness in hepatitis C virus (HCV) genotype (G) 3 infection but not in G1.
|
31479286 |
2019 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
<b>Results:</b> While the rs12979860 IFNL3 T allele was found a good marker associated with HCV-outcome together with the rs111200466 TLR2 del variant, the rs10204525 PD-1.6 A allele was found to have an insignificant role in patients with HCV-related hepatic disorders.
|
30930876 |
2019 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
<i>IL28B</i> C/T polymorphism (rs12979860) was evaluated in circulating blood cells using a PCR-based restriction fragment length polymorphism assay.Overall <i>H. pylori</i> serology was positive in 38.1% of our HCV-infected subjects.
|
29510558 |
2018 |
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
41 patients with genotype 1 chronic hepatitis C infection from the Duke Liver Clinic were genotyped for rs12979860.
|
21750736 |
2011 |
|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients.
|
23936821 |
2013 |
|
Liver Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients.
|
23936821 |
2013 |
|
Hepatitis B, Chronic
|
|
0.050 |
GeneticVariation
|
BEFREE |
Chronic hepatitis B and IL28B rs12979860 polymorphism: preliminary study.
|
24057245 |
2013 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
In patients achieving rapid virological response, favourable CC/TT allele at rs12979860, rs8099917 was found to be predominant at both the alleles at 77%, 73.2% respectively; whereas in case of patients with relapsed HCV infection CT, TG alleles were found to be predominant.
|
24914551 |
2014 |
|
Tropical Spastic Paraparesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene.
|
26609200 |
2015 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
HCV genotype (P=0.007), IFNL3 rs12979860 (CC) (P=0.023), IFNL3 rs12980275 (AA) (P=1 × 10<sup>-4</sup>), EGFR rs11506105 (AA) (P=0.005), RVR (P=1 × 10<sup>-4</sup>), and cEVR (P=0.003) were significant predictors for SVR.
|
28703131 |
2017 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
HCV g6-infected rs12979860 major homozygous individuals had significantly higher viral loads than individuals with minor alleles (CC: 6.56 log IU/ml vs. non-CC: 5.66 log IU/ml; P = 0.021).
|
29022122 |
2018 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs12979860 genotype is a significant independent predictor of response to PEG-IFN/RBV in patients with chronic HCV infection; tests for this genotype might be used to determine the best course of treatment for patients considering antiviral therapy.
|
20176026 |
2010 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs12979860 and rs8099917 interleukin-28B polymorphisms are associated with spontaneous or interferon-alpha induced hepatitis C clearance, "CC" and "TT" genotypes (respectively) being the most favourable.
|
24387833 |
2014 |
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A comparative study of various methods for detection of IL28B rs12979860 in chronic hepatitis C.
|
28281380 |
2017 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A Mexican HCV-1-infected population treated with peg-IFNα and RVB had a low SVR rate, which was associated with the SNP rs12979860 (CC).
|
23109451 |
2013 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A new type III interferon, IFN lambda 4 (IFNL4), and its single-nucleotide polymorphism (SNP) ss469415590 causing a frame shift have been recently reported strongly to affect antiviral therapy for chronic hepatitis C virus (HCV) infection in African and Caucasian populations compared to previously reported IL-28B SNPs rs12979860 and rs8099917.
|
24646752 |
2014 |
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels.
|
27870883 |
2016 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels.
|
27870883 |
2016 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels.
|
27870883 |
2016 |
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A significant increase was observed in the frequencies of unfavorable rs12979860 genotypes/CT + TT in the chronic hepatitis C (CHC) and LTC groups.
|
28214926 |
2017 |
|
Chronic hepatitis C genotype 1
|
|
0.040 |
GeneticVariation
|
BEFREE |
A single IL28B genotype SNP rs12979860 determination predicts treatment response in patients with chronic hepatitis C Genotype 1 virus.
|
21900787 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (rs12979860 C/T) 3kb upstream of the interleukin 28B (IL-28B) gene was shown to be associated with hepatitis C clearance.
|
21146242 |
2011 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP) upstream of the IL28 gene (rs12979860) has been reported to predict sustained virological response to peginterferon-ribavirin therapy in chronic HCV patients.
|
22613675 |
2012 |
|
Hepatitis C, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (SNP) near the IL28B gene (rs12979860) strongly predicts sustained virological response to pegylated interferon plus ribavirin (pegIFN-RBV) treatment for chronic hepatitis C virus (HCV) infection.
|
20964522 |
2010 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (SNP; rs12979860) near the IL28B gene has been associated with spontaneous and treatment-induced hepatitis C virus clearance.
|
23784926 |
2013 |