rs12979860, IFNL4

N. diseases: 84
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Steatohepatitis
CUI: C2711227
Disease: Steatohepatitis
0.080 GeneticVariation BEFREE Additionally the CC(rs12979860) genotype entailed more pronounced portal inflammation (p = 0.02) and steatosis (p = 0.03). 22253715 2012
Steatohepatitis
CUI: C2711227
Disease: Steatohepatitis
0.080 GeneticVariation BEFREE However, IL28B rs12979860 and PNPLA3 rs738409 modify steatosis. 26259026 2016
Steatohepatitis
CUI: C2711227
Disease: Steatohepatitis
0.080 GeneticVariation BEFREE Two independent cohorts of 145 genotype 1 infected patients from an antifibrotic study and 180 genotype 1 patients from Duke were analyzed for the presence and severity of steatosis in relation to the rs12979860 polymorphism at the IL28B locus. 21703198 2011
Steatohepatitis
CUI: C2711227
Disease: Steatohepatitis
0.080 GeneticVariation BEFREE The IL28B rs12979860 polymorphism correlates with the biochemical activity and the presence and severity of liver steatosis in chronic hepatitis C. 22666430 2012
Steatohepatitis
CUI: C2711227
Disease: Steatohepatitis
0.080 GeneticVariation BEFREE IL28B and PNPLA3 polymorphisms were associated with the presence of any steatosis (rs12979860, p = 1.87 × 10(-7); rs2896019, p = 7.56 × 10(-4)); clinically significant steatosis (rs12979860, p = 1.82 × 10(-3); rs2896019, p = 1.27 × 10(-4)); and steatosis severity (rs12979860, p = 2.05 × 10(-8); rs2896019, p = 2.62 × 10(-6)). 22543885 2012
Steatohepatitis
CUI: C2711227
Disease: Steatohepatitis
0.080 GeneticVariation BEFREE Rs8099917 TT was also significantly associated with a lower possibility of severe steatosis (vs. TG/GG; OR, 0.580; 95%CI, 0.351-0.959; P = 0.034), whereas rs12979860 CC was not associated with hepatic steatosis (vs. CT/TT; OR, 1.062; 95%CI, 0.415-2.717; P = 0.901). 24637774 2014
Steatohepatitis
CUI: C2711227
Disease: Steatohepatitis
0.080 GeneticVariation BEFREE Multivariate logistic regression analysis showed that age (OR 1.043, 95% CI 1.012-1.075, p=0.007), triglycerides (OR 1.005, 95% CI 1.000-1.010, p=0.04), hyperuricemia (OR 5.027, 95% CI 1.839-13.742, p=0.002), IL28B rs12979860 TT/TC (OR 0.219, 95% CI 0.101-0.472, p<0.001), and steatosis grade (OR 1.704, 95% CI 1.048-2.773, p=0.03) were independently linked to moderate-severe lobular inflammation. 22314430 2012
Steatohepatitis
CUI: C2711227
Disease: Steatohepatitis
0.080 GeneticVariation BEFREE There was a borderline significant difference in the prevalence of HS in rs12979860 CC versus non-CC (40.8% versus 49.3%, P = 0.059). 28797039 2017