|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
IL-28B rs12979860 TT genotype is more prevalent in patients with advanced fibrosis, cirrhosis and HCC stages.
|
29914308 |
2018 |
|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Multivariate analysis in overall patients revealed that cirrhosis (HR: 2.94, 95% CI: 1.81-4.77, p < 0.001), IL28B rs12979860 (CT + TT) polymorphisms (HR: 3.22, 95% CI: 2.17-4.78, p < 0.001), and high APRI levels (≥2.57) (HR: 2.32, 95% CI: 1.47-3.67, p < 0.001) were independent risk factors for HCC.
|
29254684 |
2018 |
|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study aimed to determine whether IL28B rs12979860 polymorphism is also associated with development of hepatocellular carcinoma both in chronic HCV infection and in non-viral-related cirrhosis.
|
27083168 |
2017 |
|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Serum miR-126, miR-129, miR-203a, and miR-223 were upregulated in severe fibrosis (≥F3) and cirrhosis (F4) compared with F0-F2 and F0-F3, respectively. miR-221 was upregulated in ≥F3, but unchanged in F4. miR-155, miR-199a, and IFNL3 rs12979860 genotype were not significantly different in all comparisons.
|
28211229 |
2017 |
|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of this study suggest that IL28B rs12979860 TT or rs12980275 GG may play an important protective role against the development of advanced fibrosis and even cirrhosis.
|
28253210 |
2017 |
|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this phase 3, randomized, open-label, noninferiority study, 602 patients were randomly assigned (2:1) to daclatasvir vs telaprevir, stratified by IL28B rs12979860 host genotype (CC vs non-CC), cirrhosis status (compensated cirrhosis vs no cirrhosis), and HCV GT1 subtype (GT1a vs GT1b).
|
27022224 |
2016 |
|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
IL28B genetic variations (rs12979860) were genotyped by pyrosequencing of DNA samples from 137 individuals with chronic HBV infection [50 inactive carriers (IC), 34 chronic hepatitis B (CHB), 27 cirrhosis, 26 hepatocellular carcinoma (HCC)], and 19 healthy controls.
|
25837166 |
2015 |
|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, fibrosis, and hepatocellular carcinoma (HCC) in chronic hepatitis C. Whether these SNPs independently or in combination predict clinical deterioration in hepatitis C virus (HCV)-related cirrhosis is unknown.
|
25504078 |
2014 |
|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients.
|
23936821 |
2013 |
|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
IL-28B rs12979860 C/T polymorphism T allele is more prevalent in patients with viral cirrhosis due to HCV in comparison to other aetiologies and to patients with mild chronic hepatitis C. Among OLT patients, carriage of this allele seems to augment the risk of developing HCC.
|
21146242 |
2011 |
|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, the rs12979860 C/T polymorphism in the IL28B gene has been linked to progression towards cirrhosis in HCV mono-infected patients and to treatment response of HCV-infection in HIV/HCV co-infected patients.
|
21813376 |
2011 |
|
Cirrhosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The IL28B rs12979860 CC genotype is associated with a higher prevalence of cirrhosis in HIV-HCV-coinfected patients than CT/TT genotypes, suggesting that IL28B CC carriers may experience a more rapid progression of HCV-related liver fibrosis, perhaps as result of increased liver inflammation.
|
21592993 |
2011 |