|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
We developed a triplex high-resolution melting assay for the simultaneous assessment of three genetic polymorphisms related to the response to treatment and development of advanced fibrosis in CHC: IFNL3 rs12979860, ABCB11 rs2287622, and RNF7 rs16851720.
|
28860020 |
2017 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine whether two polymorphisms of the human interferon lambda 4 (IFNL4) gene (rs12979860 and rs8099917) can predict sustained virologic response (SVR) following antiviral therapy in patients with inherited bleeding disorder and chronic hepatitis C (CHC).
|
27735085 |
2017 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, only rs12979860 CC genotype was the independent factors for NR in GT-1 CHC infection (OR, 8.985; p = 0.008).
|
29284412 |
2017 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, the distribution of IL28B SNPs (rs12979860 and rs12980275) and HLA rs4273729 in rapid virologic response (RVR), complete early virologic response (cEVR) and sustained virologic response (SVR) in HCV Iranian patients with CHC virus infection was assessed.
|
27714501 |
2017 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
Compared with HCV viral genotype, ALT level and baseline viral load, IL-28B rs12979860 is more suitable for predicting antiviral efficacy in children with CHC.
|
27877087 |
2016 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
Vitamin D related (VDR rs2228570 and CYP2R1 rs10741657) and IL28B rs12979860 genes polymorphisms accurately assure SVR in naïve CHC G4 patients treated with low cost standard therapy.
|
26911666 |
2016 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels.
|
27870883 |
2016 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rate of sustained virologic response (SVR) was higher for the CC genotype of IL28B rs12979860 polymorphisms than for non-CC in both genotype 1 (60.6% vs. 29.4%, P < 0.001) and non-genotype 1 (69.4% vs. 49.1%, P < 0.05) CHC.
|
26339796 |
2015 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the single-nucleotide polymorphism (SNP) rs12979860 in the IL28B gene is a better predictor of sustained virological response to treatment of chronic hepatitis C (CHC) than other baseline factors, some CHC patients with the favorable C allele cannot achieve a sustained virological response when treated with peginterferon plus ribavirin.
|
25687192 |
2015 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped 544 chronic hepatitis C (CHC) patients, 78 spontaneous hepatitis C clearance (SHC) patients and 215 healthy controls for CD24 gene variants at positions -P534, P170, P1527 and IFNL3 rs12979860 by pyrosequencing.
|
25872416 |
2015 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
The HRM assay described herein is rapid, inexpensive, sensitive and accurate for detecting rs12979860 alleles in CHC patients.
|
25773839 |
2015 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
IL28B rs12979860 CC genotype is a significant predictor for SVR and RVR in Chinese Han patients with CHC.
|
25312023 |
2015 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
The intra-hepatic level of expression of interferon stimulated genes (ISGs) and the rs12979860 CC genotype located within IFNL3 have been associated with sustained virological response (SVR), in patients with CHC.
|
25844942 |
2015 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
To compare the role of IFNL4 polymorphism with the two commonly used IL28B SNPs rs12979860 and rs8099917 on response to PEG/RBV in patients with CHC.
|
24205831 |
2014 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotype and allele distributions for both rs12979860 and rs8099917 were significantly different between the control and CHC p</span>atient groups, with significantly higher genotype frequencies of CC and TT in the controls (P = 0.037 and 0.046, respectively) and of TT and GG in the CHC patients (P = 0.0009 and 0.0001, respectively).
|
24259970 |
2013 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that IL-28B rs12979860</span> CC and rs8099917 TT were associated with high SVR rate in CHC</span> genotype 1/4.
|
22842190 |
2012 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped chronic hepatitis C (CHC) genotype 1 patients with PegIFN/R treatment-induced clearance (n = 417) and treatment failure (n = 493), and 234 individuals with spontaneous clearance, for HLA-C C1 versus C2, presence of inhibitory and activating KIR genes, and two IL28B SNPs, rs8099917 and rs12979860.
|
21931540 |
2011 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
We previously found that LDL cholesterol levels were higher in chronic hepatitis C (CHC) patients with the CC genotype at the rs12979860 polymorphism, located proximal to the IL28 gene.
|
21703198 |
2011 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms near the IL28B gene (e.g. rs12979860) encoding interferon λ3 have recently been associated with both spontaneous clearance and treatment response to pegIFN/RBV in chronic hepatitis C (CHC) patients.
|
21750736 |
2011 |
|
Pseudohyperkalemia Cardiff
|
|
0.100 |
GeneticVariation
|
BEFREE |
IL28B genotyping (rs12979860) and whole-genome RNA expression were performed using liver biopsies from 61 North American patients with CHC.
|
20931559 |
2010 |