Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE Polymorphism rs13266634 in SLC30A8 causes abnormal synthesis, maturation and secretion of insulin, resulting in decrease in efficiency of glucose metabolism and diabetes. 30633652 2020
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192). 31823921 2019
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE Moreover, overexpression of human ZnT8 diabetes high-risk allele R325W increased 5-HT levels relative to the low-risk allele in RIN14B cells. 30936149 2019
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE ZnT8 Arg325Trp polymorphism influences zinc transporter expression and cytokine production in PBMCs from patients with diabetes. 30142362 2018
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE We found that the diabetes risk genotype C/C at rs13266634 is associated with higher islet Zn concentration (C/C genotype: 16792 ± 1607, n = 22, C/T genotype: 11221 ± 1245, n = 18 T/T genotype: 11543 ± 6054, n = 3, all values expressed as mean nmol/g protein ± standard error of the mean, p = 0.040 by ANOVA). 28352089 2017
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE Thus, the common polymorphism rs13266634 was associated with lowered beta cell function and a 14% increase in diabetes abundance per risk (C) allele. 25287711 2015
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE Zinc supplementation appears to affect the early insulin response to glucose differentially by rs13266634 genotype and could be beneficial for diabetes prevention and/or treatment for some individuals based on SLC30A8 variation. 25348609 2015
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE Associations between ZnT8 antibody (ZnT8A), phenotype and the genetic variant rs13266634 in the SLC30A8 gene have primarily been studied in patients with young-onset diabetes. 23061550 2013
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE We searched all the publications about the association between SLC30A8 and diabetes from PubMed, and evaluated the association between SLC30A8 rs13266634 C/T polymorphism and T2DM, IGT and T1DM, respectively, by meta-analysis of all the validated studies. 21131091 2011
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE For four candidate SNPs (rs780094, rs10830963, rs7903146, and rs4607517), the strength of association between genotype and glucose was significantly (P-interaction<0.05) different in those with and without prevalent diabetes, and for all five fasting glucose candidate SNPs (rs780094, rs10830963, rs560887, rs4607517, and rs13266634) the association with measured fasting glucose was more significant in the smaller sample without prevalent diabetes than in the larger combined sample of those with and without diabetes. 20839289 2010
Diabetes Mellitus
CUI: C0011849
Disease: Diabetes Mellitus
0.100 GeneticVariation BEFREE Moreover, ZnT8A-COOH-positive children who carried homozygous SLC30A8 SNP rs13266634 genotypes progressed faster to diabetes than those who were heterozygous (59% [95% CI 42.3-75.7%] vs 22% [95% CI 0-44.3%] within 5 years; p = 0.01). 19590848 2009