Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
In addition, we observed a genetic interaction between BLK (rs2736340T/C, rs13277113A/G) and BANK1 (R61H and A383T) associated with susceptibility to SLE.
|
31134304 |
2019 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
We observed more frequent heterozygous GA genotypic pattern (rs13277113) in our SLE patients compared to that in controls; and it was associated with disease flares.
|
27864698 |
2017 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
The results revealed that the BLK rs13277113 and rs2736340 polymorphisms increased the risk of autoimmune diseases in the total analysis (A vs G: OR = 1.33, 95% CI = 1.27-1.39, P < .01; T vs C: OR = 1.34, 95% CI = 1.27-1.41, P < .01), and rs4840568 was positively associated with systemic lupus erythematosus (SLE) (A vs G: OR = 1.32, 95% CI = 1.22-1.43, P = .01).
|
28885337 |
2017 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.
|
23053960 |
2012 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
GWASDB |
Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.
|
23053960 |
2012 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
Minor alleles of rs13277113 (P = 4.2E-05, odds ratio [OR] 0.66, [95% CI 0.54-0.81]) and rs4840568 (P = 7.1E-05, OR 0.67, [95% CI 0.55-0.82]) were found to be protective against SLE.
|
22313735 |
2012 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
On the assessment of available evidence, the authors concluded that moderate evidence exists for an association between the BLK rs13277113, rs2248932 variants and SLE.
|
21152986 |
2011 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
Polymorphisms of rs13277113 in NCF2 gene were associated with arthritis and autoantibody production, but not disease risk, of SLE in Chinese population.
|
20842512 |
2011 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
Our data confirmed association of STAT4 (rs7574865, odds ratio (OR) =1.71, P=3.55 x 10(-23)) and BLK (rs13277113, OR=0.77, P=1.34 x 10(-5)) with SLE.
|
19225526 |
2009 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
GWASDB |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
BEFREE |
Because both the risk allele frequency and the OR were higher in Japanese than in Caucasians, the PAR% of rs13277113 was estimated to be much higher in Japanese (35.4%) than in Caucasians (16.2%), and the second highest among the 6 confirmed SLE susceptibility genes in Japanese.
|
19180478 |
2009 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
|
18204098 |
2008 |
Lupus Erythematosus, Systemic
|
|
0.890 |
GeneticVariation
|
GWASDB |
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
|
18204098 |
2008 |
Mucocutaneous Lymph Node Syndrome
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study identifies three new risk loci for Kawasaki disease.
|
22446962 |
2012 |
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In summary, our results indicated that the BLK rs13277113 polymorphism was involved in the genetic background of RA in Chinese population and the association of BANK1 rs3733197 polymorphism with RA was dependent on the genotype of BLK rs13277113 polymorphism, highlighting B-cell response implicated in the pathogenesis of RA.
|
28925718 |
2017 |
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
In individuals carrying the BLK rs13277113 GG genotype, presence of the BANK1 rs3733197 G allele increased the risk of RA (odds ratio 1.21 [95% confidence interval 1.04-1.41], P = 0.015.
|
23646104 |
2013 |
Rheumatoid Arthritis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We replicated the genetic association with rs13277113 (p = 0.0009, OR 1.46) and rs2736340 (p = 0.0001, OR 1.63) from C8orf13-BLK (8p23.1, associated with RA and systemic lupus erythematosus), and rs763361 (p = 0.03) from CD226 (18q22.3, associated with multiple sclerosis and type 1 diabetes) in the Colombian population.
|
21765104 |
2011 |
Dermatomyositis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our present study demonstrated that strong allele association was observed in overall PM/DM and PM patients for rs2736340 (P c = 6.48 × 10(-3); P c = 0.013, respectively), rs7812879 (P c = 0.017; P c = 0.034, respectively) and rs13277113 (P c = 0.011; P c = 0.047, respectively).
|
25846585 |
2015 |
Polymyositis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our present study demonstrated that strong allele association was observed in overall PM/DM and PM patients for rs2736340 (P c = 6.48 × 10(-3); P c = 0.013, respectively), rs7812879 (P c = 0.017; P c = 0.034, respectively) and rs13277113 (P c = 0.011; P c = 0.047, respectively).
|
25846585 |
2015 |
Dermatomyositis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The C8orf13-BLK rs13277113 A and STAT4 rs7574865 T alleles had an additive effect on polymyositis/dermatomyositis susceptibility.
|
24632671 |
2014 |
Polymyositis
|
|
0.020 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism in C8orf13-BLK (dbSNP ID: rs13277113) was investigated in the Japanese population using a TaqMan assay in 283 polymyositis patients, 194 dermatomyositis patients, and 656 control subjects.
|
24632671 |
2014 |
Systemic Scleroderma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor allele frequencies for rs13277113 revealed an association restricted to the dcSSc subtype (P = 0.012, odds ratio [OR] 1.29) in the French sample.
|
21480188 |
2011 |
Systemic Scleroderma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The "A" allele at rs13277113 variant was associated with SSc in the U.S. series only (P = 3.6 x 10(-4), OR 1.32, 95% CI 1.1-1.6) and was significant in the combined analyses of the two series (P = 2.0 x 10(-3); OR 1.20, 95% CI 1.1-1.3).
|
19796918 |
2010 |