Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
849 CAD patients undergoing revascularization (660 with CAC and 189 without CAC) were enrolled in a cohort study to test its association with cardiovascular events in CAD patients with and without CAC in a 3-year follow-up. rs1333049 was significantly associated with the incidence of cardiovascular events in non-target vessels in patients with CAC (hazard ratio = 1.44, 95%CI, 1.08-1.91, P = 0.012), but not in those without CAC.
|
24732910 |
2014 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A replication study and a meta-analysis of the association between the CDKN2A rs1333049 polymorphism and coronary heart disease.
|
24930384 |
2014 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI.
|
19548844 |
2009 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23-26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population.
|
24163049 |
2014 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association Study Between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population.
|
28639227 |
2017 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Further subgroup analyses showed that rs1333040, rs1333049 and rs2383207 polymorphisms were significantly correlated with the risk of CAD in East Asians, rs2383206 and rs10757274 polymorphisms were significantly correlated with the risk of CAD in West Asians, while rs2383206, rs10757274 and rs10757278 polymorphisms were significantly correlated with the risk of CAD in Caucasians.
|
30814313 |
2019 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease.
|
29472232 |
2018 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Higher FRS and PWV and the presence of rs2943634 risk allele were independent predictors of CAD (Nagelkerke R(2) 0·252, P < 0·001), while higher FRS and the presence of rs1333049 risk allele were independent predictors of multivessel CAD (Nagelkerke R(2) 0·190, P < 0·001).
|
24942486 |
2014 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, the effect of rs1333049 on clinical outcomes in patients with established coronary disease has yet to be determined.
|
20400779 |
2010 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In all, 950 patients with early onset CAD (age 56.1 +/- 9.6 years) and an independent sample of 764 patients with late onset CAD (age 70.0 +/- 8.0 years) were enrolled from the cardiac catheterization laboratories at the University of Ottawa Heart Institute from April 15, 2006, to August 15, 2008, and genotyped for the single nucleotide polymorphism rs1333049 9p21 risk variant.Angiographers were blinded to genotype.
|
20670758 |
2010 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the case-control study, only haplotypes at 1 block tagged by rs1333049 associated with CAD more so than MI.
|
23729007 |
2013 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls).
|
18264662 |
2008 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Of 1095 CAD diagnosis-free participants, 52% were heterozygous (CG) and 22% were homozygous (CC) for the risk C allele rs1333049.
|
21852414 |
2011 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Of thousands of chromosomal loci studied, the same locus had the strongest association with coronary artery disease in both the WTCCC and the German studies: chromosome 9p21.3 (SNP, rs1333049) (P=1.80x10(-14) and P=3.40x10(-6), respectively).
|
17634449 |
2007 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data from two populations show that variant rs1333049 is significantly associated with angiographically characterized CAD.
|
19135198 |
2009 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population.
|
28962556 |
2017 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Pooled overall analyses showed that rs1333040 (dominant model: P < 0.0001; recessive model: P < 0.0001; allele model: P < 0.0001), rs1333049 (dominant model: P = 0.02; allele model: P = 0.02) and rs2383207 (additive model: P = 0.004; allele model: P = 0.03) polymorphisms were significantly associated with the likelihood of CAD.
|
30387168 |
2019 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI).
|
20231156 |
2010 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The leading coronary artery disease-associated SNP rs1333049 was associated with coronary artery disease; however, none of the 9p21 SNP evaluated in the present study were associated with extreme longevity.
|
25257646 |
2015 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The meta-analysis of the rs1333049 SNP in 12,0</span>04 cases and 28,949 controls increased the overall level of evidence for association with CAD to P=6.04x10(-10) (odds ratio, 1.24; 95% confidence interval, 1.20 to 1.29).
|
18362232 |
2008 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The polymorphic variants of Apo-A5; rs2266788 (C), 9p21.3; rs1333049 (C) rs2383207 (A) are associated with CAD, its severity and exerts the risk of MI in North Indian population.
|
29309886 |
2018 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs2383207 and rs1333049 SNPs on 9p21 chromosome were significantly associated with the risk and severity of CAD in the Turkish population.
|
25333979 |
2015 |