Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Further subgroup analyses showed that rs1333040, rs1333049 and rs2383207 polymorphisms were significantly correlated with the risk of CAD in East Asians, rs2383206 and rs10757274 polymorphisms were significantly correlated with the risk of CAD in West Asians, while rs2383206, rs10757274 and rs10757278 polymorphisms were significantly correlated with the risk of CAD in Caucasians.
|
30814313 |
2019 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We genotyped the CAD-associated variants at the LPA (rs10455872) and 9p21 loci (rs1333049) in the GeneCAST (Genetics of Calcific Aortic STenosis) Consortium and conducted a meta-analysis for their association with AVS.
|
30482443 |
2019 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Pooled overall analyses showed that rs1333040 (dominant model: P < 0.0001; recessive model: P < 0.0001; allele model: P < 0.0001), rs1333049 (dominant model: P = 0.02; allele model: P = 0.02) and rs2383207 (additive model: P = 0.004; allele model: P = 0.03) polymorphisms were significantly associated with the likelihood of CAD.
|
30387168 |
2019 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The polymorphic variants of Apo-A5; rs2266788 (C), 9p21.3; rs1333049 (C) rs2383207 (A) are associated with CAD, its severity and exerts the risk of MI in North Indian population.
|
29309886 |
2018 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease.
|
29472232 |
2018 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association Study Between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population.
|
28639227 |
2017 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population.
|
28962556 |
2017 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We examined the prognostic values of the rs9508025 and rs1333049 variants that were found to be associated with coronary artery disease (CAD) risk in a previous Korean genome-wide association study.
|
27736948 |
2016 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs2383207 and rs1333049 SNPs on 9p21 chromosome were significantly associated with the risk and severity of CAD in the Turkish population.
|
25333979 |
2015 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The leading coronary artery disease-associated SNP rs1333049 was associated with coronary artery disease; however, none of the 9p21 SNP evaluated in the present study were associated with extreme longevity.
|
25257646 |
2015 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Higher FRS and PWV and the presence of rs2943634 risk allele were independent predictors of CAD (Nagelkerke R(2) 0·252, P < 0·001), while higher FRS and the presence of rs1333049 risk allele were independent predictors of multivessel CAD (Nagelkerke R(2) 0·190, P < 0·001).
|
24942486 |
2014 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
849 CAD patients undergoing revascularization (660 with CAC and 189 without CAC) were enrolled in a cohort study to test its association with cardiovascular events in CAD patients with and without CAC in a 3-year follow-up. rs1333049 was significantly associated with the incidence of cardiovascular events in non-target vessels in patients with CAC (hazard ratio = 1.44, 95%CI, 1.08-1.91, P = 0.012), but not in those without CAC.
|
24732910 |
2014 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A replication study and a meta-analysis of the association between the CDKN2A rs1333049 polymorphism and coronary heart disease.
|
24930384 |
2014 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23-26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population.
|
24163049 |
2014 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP), rs1333049 on chromosome 9p21.3 has been strongly associated with CAD and myocardial infarction.
|
23787071 |
2013 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the case-control study, only haplotypes at 1 block tagged by rs1333049 associated with CAD more so than MI.
|
23729007 |
2013 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We examined whether genotype at the lead CAD-associated single nucleotide polymorphism (rs1333049) in 9p21 was associated with: 1) basal levels of IFN-I in plasma from 148 healthy male subjects; 2) induction of IFN-I by Toll-like receptor stimulants in peripheral blood mononuclear cells of 60 healthy volunteers assessed by enzyme-linked immunosorbent assay, quantitative polymerase chain reaction, Western blot, and IFN-I bioassay; and 3) enhancer activity of predicted IFN regulatory factor 3/7 binding sites within the 9p21 CAD risk region in reporter assays.
|
23933542 |
2013 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Of 1095 CAD diagnosis-free participants, 52% were heterozygous (CG) and 22% were homozygous (CC) for the risk C allele rs1333049.
|
21852414 |
2011 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
To investigate whether the SNP rs1333049 located on the 9p21 chromosome is an independent risk factor for CAD in a Portuguese population.
|
21874923 |
2011 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP) rs1333049 (C/G) on chromosome 9p21 has been implicated in previous studies to be associated with CAD.
|
21558165 |
2011 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study demonstrated a significant association of rs1333049 polymorphism on chromosome 9p21.3 with CAD in Chinese diabetic and non-diabetic patients.
|
21362310 |
2011 |
Coronary Artery Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI).
|
20231156 |
2010 |