|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Significant associations with breast cancer were observed for rs13387042 and rs4415084 with OR (95% CI) per-allele 1.29 (1.00-1.66) and 0.83 (0.71-0.97), respectively.
|
27022606 |
2016 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We found that the rs13387042-2q35(G/A) SNP was associated with breast cancer risk only among postmenopausal women who never used hormone therapy [per A allele OR: 0.94 (95% confidence intervals, 0.74-1.20), 1.20 (0.94-1.53), and 1.49 (1.28-1.75) for current, former, and never hormone therapy users, respectively, Pinteraction 0.002] and premenopausal women who breastfed >12 months [OR: 1.01 (0.72-1.42), 1.19 (0.98-1.45), and 1.69 (1.26-2.26) for never, <12 months, and >12 months breastfeeding, respectively, Pinteraction 0.014].
|
26364163 |
2015 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Five of the 17 SNPs were significantly associated (P ≤ 0.05) with overall breast cancer in the same direction as previously reported: rs13387042 (2q35/TNP1), rs4973768 (3p24/SLC4A7), rs2046210 (6q25/ESR1), rs1219648 (10q26/FGFR2), and rs4784227 (16q12/TOX3).
|
24510657 |
2015 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
These results indicate an additive effect of the TOX3 rs3803662 and 2q35 rs13387042</span> alleles for BC risk.
|
24532140 |
2014 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis demonstrated that the A allele of 2q35-rs13387042 is a risk factor associated with increased breast cancer susceptibility.
|
23976942 |
2013 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Our findings demonstrated that rs13387042-A allele is a risk-conferring factors for the development of BC, especially in Asians, Caucasians and Hispanic whites.
|
23894282 |
2013 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2).
|
23593120 |
2013 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We confirmed associations between rs13387042 (2q35), rs4973768 (SLC4A7), rs10941679 (5p12), rs2981582 (FGFR2), rs3817198 (LSP1), rs3803662 (TOX3), and rs6504950 (STXBP4) with breast cancer.
|
23893088 |
2013 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35), rs4973768 (SLC4A7), rs6504950 (COX11) and rs10941679 (5p12) were genotyped for 25 853 BC patients with the available follow-up; 62 other SNPs, which have been suggested as BC risk SNPs by a GWAS or as candidate SNPs from individual studies, were genotyped for replication purposes in subsets of these patients.
|
22532573 |
2012 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Blood samples can be used for determining the genotypes for 2q35-rs13387042 in patients for risk of breast cancer.
|
22287734 |
2012 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Overall, all of the five SNPs contributed to breast cancer susceptibility in a dominant genetic model (2q35, rs13387042: adjusted OR = 1.26, P = 0.006; 3q24.1, rs2307032: adjusted OR = 1.24, P = 0.005; 6q22.33, rs2180341: adjusted OR = 1.22, P = 0.006; 6q25.1, rs2046210: adjusted OR = 1.51, P = 2.40 × 10-8; 10q26.13, rs2981582: adjusted OR = 1.31, P = 1.96 × 10-4).
|
22269215 |
2012 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
|
21263130 |
2011 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We focus on TNRC9 rs3803662, FGFR2 rs1219648 and rs2981582, MAP3K1 rs889312, and 2q35 rs13387042, to replicate in the 4-Corner's Breast Cancer Study of Hispanic (N = 565 cases and 714 controls) and non-Hispanic white (NHW) women (N = 1177 cases and 1330 controls).
|
21475998 |
2011 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies five new breast cancer susceptibility loci.
|
20453838 |
2010 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Two single-nucleotide polymorphisms, rs13387042 (2q35) and rs1219648 (FGFR2 gene), were found to be associated with breast cancer risk.
|
19789366 |
2009 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
The best fit for the association of SNP rs13387042 at 2q35 with breast cancer risk was a dominant model for both BRCA1 and BRCA2 mutation carriers (BRCA1: HR = 1.14, 95% CI: 1.04-1.25, P = 0.0047; BRCA2: HR = 1.18 95% CI: 1.04-1.33, P = 0.0079).
|
19656774 |
2009 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
|
19330030 |
2009 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We found strong evidence of association between rs13387042 and breast cancer in white women of European origin (per-allele OR = 1.12, 95% confidence interval [CI] = 1.09 to 1.15; P(trend) = 1.0 x 10(-19)).
|
19567422 |
2009 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Two SNPs consistently associated with breast cancer: approximately 25% of individuals of European descent are homozygous for allele A of rs13387042 on chromosome 2q35 and have an estimated 1.44-fold greater risk than noncarriers, and for allele T of rs3803662 on 16q12, about 7% are homozygous and have a 1.64-fold greater risk.
|
17529974 |
2007 |
|
Breast Carcinoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
At present, no genes have been identified in the linkage disequilibrium block containing rs13387042. rs3803662 is near the 5' end of TNRC9 , a high mobility group chromatin-associated protein whose expression is implicated in breast cancer metastasis to bone.
|
17529974 |
2007 |