|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Logistic regression analysis was conducted to analyze the risk factors influencing the occurrence of PCOS as well as those influencing the efficacy of IVF-ET. rs13405728, rs12478601, and family history of DM were influencing factors for the occurrence of PCOS.
|
30844144 |
2019 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Results of the meta-analysis showed a significant association between PCOS and rs13405728 (for G vs. A: OR = 0.735, 95% CI = 0.699-0.773, p<.001; For GG vs. AG + AA: OR = 0.578, 95% CI = 0.436-0.767, p<.001; For GG + AG vs. AA: OR = 0.817, 95% CI = 0.741-0.901, p<.001) in Asian populations, and rs4539842 (for ins/ins vs. ins/non + non/non: OR = 0.686, 95% CI = 0.483-0.974, p=.035) and rs2293275 (for AA vs. AG + GG: OR = 4.115, 95% CI = 1.033-16.38, p=.045) in Caucasian populations, respectively.
|
30182769 |
2019 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
<b>Conclusions:</b> Genetic variants of PCOS (rs13405728 in <i>LHCGR</i> gene; rs13429458 in <i>THADA</i> gene and rs2479106 in <i>DENND1A</i> gene) may not be involved in the development of preeclampsia in Han Chinese women.
|
29727258 |
2019 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
The present study suggested that the SNP rs13405728 in the LHCGR gene was associated with PCOS in Hui ethnic women, and its TT genotype characterized with higher level of TT, TG and LDL.
|
25978310 |
2015 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Variants of rs3802457 in C9orf3 locus (P = 5.99×10-4) and rs13405728 in LHCGR locus (P = 3.73×10-4) were significantly associated with PCOS after the strict Bonferroni correction in our data set.
|
26474478 |
2015 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a previous genome-wide association study, the SNP variants rs13429458, rs12478601, rs2479106, rs10818854 and rs13405728 in the THADA, DENND1A and LHCGR genes were identified as being independently associated with PCOS.
|
23208300 |
2013 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although the marker with the strongest association in the Chinese PCOS genome-wide association study (rs13405728) was not informative in the European populations, we identified and genotyped three markers (rs35960650, rs2956355, and rs7562879) within 5 kb of rs13405728.
|
23118426 |
2013 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to explore the polycystic ovary syndrome (PCOS) related single nucleotide polymorphisms (SNPs) rs13405728 (in gene LHCGR), rs13429458 (in gene THADA) and rs2479106 (in gene DENND1A) in women with endometrial carcinoma.
|
22902918 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
Other risk variants at 2p16.3 (rs13405728), 2p21 (rs12468394, rs12478601, and rs13429458), and 9q33.3 (rs2479106), or variants correlated with them, did not associate with PCOS.
|
22547425 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
|
22885925 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
|
22885925 |
2012 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
GWASCAT |
We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P(meta) = 7.55 × 10⁻²¹, odds ratio (OR) 0.71); 2p21 (rs13429458, P(meta) = 1.73 × 10⁻²³, OR 0.67); and 9q33.3 (rs2479106, P(meta) = 8.12 × 10⁻¹⁹, OR 1.34).
|
21151128 |
2011 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
GWASDB |
We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P(meta) = 7.55 × 10⁻²¹, odds ratio (OR) 0.71); 2p21 (rs13429458, P(meta) = 1.73 × 10⁻²³, OR 0.67); and 9q33.3 (rs2479106, P(meta) = 8.12 × 10⁻¹⁹, OR 1.34).
|
21151128 |
2011 |
|
Polycystic Ovary Syndrome
|
|
0.900 |
GeneticVariation
|
BEFREE |
We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P(meta) = 7.55 × 10⁻²¹, odds ratio (OR) 0.71); 2p21 (rs13429458, P(meta) = 1.73 × 10⁻²³, OR 0.67); and 9q33.3 (rs2479106, P(meta) = 8.12 × 10⁻¹⁹, OR 1.34).
|
21151128 |
2011 |