rs137852578, AR

N. diseases: 10
Disease: Prostatic Neoplasms ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Prostatic Neoplasms
CUI: C0033578
Disease: Prostatic Neoplasms
0.020 GeneticVariation BEFREE The gene expression profile of AR-E231G prostate tissue from 12-week-old mice was compared to an equivalent profile from mice expressing the AR-T857A receptor variant (analogous to the AR-T877A variant in LNCaP cells), which do not develop prostate tumors. 22275114 2012
Prostatic Neoplasms
CUI: C0033578
Disease: Prostatic Neoplasms
0.020 GeneticVariation BEFREE Human LNCaP cells, extensively used as a model for androgen-dependent prostate tumor, express the androgen receptor (AR) mutant T877A promiscuously transactivated by estrogens and other ligands, which may further facilitate cancer progression. 12391264 2002