|
Gestational Diabetes
|
|
0.080 |
GeneticVariation
|
BEFREE |
Pooled overall analyses showed that rs1387153 (dominant model: <i>p</i> = 0.0002, OR = 0.78, 95% CI: 0.68-0.89; recessive model: <i>p</i> < 0.0001, OR = 1.46, 95% CI: 1.24-1.73; allele model: <i>p</i> < 0.0001, OR = 0.78, 95% CI: 0.72-0.84), rs4753426 (recessive model: <i>p</i> = 0.01, OR = 1.75, 95% CI: 1.14-2.68; allele model: <i>p</i> = 0.01, OR = 0.69, 95% CI: 0.51-0.93), and rs10830963 (dominant model: <i>p</i> < 0.0001, OR = 0.72, 95% CI: 0.65-0.78; recessive model: <i>p</i> < 0.0001, OR = 1.56, 95% CI: 1.40-1.74; allele model: <i>p</i> < 0.0001, OR = 0.73, 95% CI: 0.69-0.78) variants were all significantly associated with the susceptibility to GDM.
|
30991439 |
2019 |
|
Gestational Diabetes
|
|
0.080 |
GeneticVariation
|
BEFREE |
In addition, we confirmed three variants, rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs4506565 (TCF7L2), that had previously been significantly associated with GDM risk.
|
29947923 |
2018 |
|
Gestational Diabetes
|
|
0.080 |
GeneticVariation
|
BEFREE |
The further meta-analysis included other five studies showed that the frequency of MTNR1B rs10830963 G allele and rs1387153 T allele are higher in GDM patients.
|
26563312 |
2016 |
|
Gestational Diabetes
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our results showed a significant association between the three genetic variants and GD</span>M risk, rs10830963 with a P-value less than 0.0001, rs1387153 with a P-value of 0.0002, and rs1801278 with a P-value of 0.001.
|
25146448 |
2014 |
|
Gestational Diabetes
|
|
0.080 |
GeneticVariation
|
BEFREE |
Risk variants rs10830963 and rs1387153 of MTNR1B were significantly associated with GDM (odds ratio (OR)=1.62 (95% CI 1.34-1.96), P=4.5 × 10⁻⁷ and 1.38 (1.14-1.66), P=7.6 × 10⁻⁴ respectively).
|
23761423 |
2013 |
|
Gestational Diabetes
|
|
0.080 |
GeneticVariation
|
BEFREE |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (Gly972Arg, IRS1) were significantly associated with a higher risk of GDM.
|
23690305 |
2013 |
|
Gestational Diabetes
|
|
0.080 |
GeneticVariation
|
BEFREE |
One hundred seventy-five unrelated pregnant Greek women (77 with GDM and 98 non-diabetic control subjects) were enrolled and the SNaPshot method was employed in order to investigate the association between GDM and the variants rs10830963 and rs1387153 in the MTNR1B locus.
|
22450346 |
2012 |
|
Gestational Diabetes
|
|
0.080 |
GeneticVariation
|
BEFREE |
We found significant associations between the two genetic variants and GDM, rs10830963, with a corrected P value of 0.0001, and rs1387153, with the corrected P value of 0.0008.
|
21658282 |
2011 |