|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
These data suggest that the <i>MTNR1B</i> rs10830963 and rs1387153 polymorphisms are associated with repaglinide monotherapy efficacy in Chinese patients with T2DM.
|
31787898 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
Five SNPs in KCNQ1 (rs2237892), CDK2A/2B (rs108116610, SLC30A8 (rs13266634), TCF7L2 (rs7903146) and MTNR1B (rs1387153) were found to be marginally associated with risk of developing T2D, with odds ratios ranging from 1.43 to 2.02 (p = 0.047 to 3.0 × 10-4) with adjustments for age, sex, and body mass index.
|
29871606 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
Variants rs10830963 (C/G) and rs1387153 (C/T) in MTNR1B have been shown with an increased risk of developing type 2 diabetes and gestational diabetes mellitus.
|
26563312 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
|
23300278 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
Two common variants (rs1387153, rs10830963) in MTNR1B have been reported to have independent effects on fasting blood glucose (FBG) levels with increased risk to type 2 diabetes (T2D) in recent genome-wide association studies (GWAS).
|
21558052 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
Two SNPs in melatonin receptor 1B gene, rs10830963 and rs1387153 showed significant associations with fasting plasma glucose levels and the risk of Type 2 Diabetes Mellitus (T2DM) in previous studies.
|
21658282 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
Of the 37 T2D risk alleles, two showed nominally significant positive associations with pancreatic cancer risk (FTO rs8050136 per-allele OR = 1.12; CI: 1.02-1.23; MTNR1B rs1387153 OR = 1.11; CI: 1.00-1.23) and one showed an inverse association (BCL11A rs243021 OR = 0.88; CI: 0.80-0.97).
|
21445555 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
GWASDB |
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
|
21647700 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
GWASDB |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
To investigate the two variants (rs1387153 and rs10830963) near/in the melatonin receptor 1B gene (MTNR1B) and to determine their association with Type 2 diabetes, as well as with the regulation of fasting plasma glucose (FPG) in Han Chinese subjects.
|
20536959 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.880 |
GeneticVariation
|
BEFREE |
In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15, 95% CI = 1.08-1.22, P = 6.3 x 10(-5), cases N = 6,332) and risk of developing hyperglycemia or diabetes over a 9-year period (hazard ratio (HR) = 1.20, 95% CI = 1.06-1.36, P = 0.005, incident cases N = 515).
|
19060909 |
2009 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
22885924 |
2012 |
|
Metabolic Syndrome X
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
|
21386085 |
2011 |
|
Metabolic Syndrome X
|
|
0.800 |
GeneticVariation
|
GWASDB |
A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
|
21386085 |
2011 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.
|
19060909 |
2009 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.
|
19060909 |
2009 |
|
Fasting blood glucose measurement
|
|
0.800 |
GeneticVariation
|
GWASDB |
Variants in MTNR1B influence fasting glucose levels.
|
19060907 |
2009 |
|
Fasting blood sugar result
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
22885924 |
2012 |
|
Gestational Diabetes
|
|
0.080 |
GeneticVariation
|
BEFREE |
Pooled overall analyses showed that rs1387153 (dominant model: <i>p</i> = 0.0002, OR = 0.78, 95% CI: 0.68-0.89; recessive model: <i>p</i> < 0.0001, OR = 1.46, 95% CI: 1.24-1.73; allele model: <i>p</i> < 0.0001, OR = 0.78, 95% CI: 0.72-0.84), rs4753426 (recessive model: <i>p</i> = 0.01, OR = 1.75, 95% CI: 1.14-2.68; allele model: <i>p</i> = 0.01, OR = 0.69, 95% CI: 0.51-0.93), and rs10830963 (dominant model: <i>p</i> < 0.0001, OR = 0.72, 95% CI: 0.65-0.78; recessive model: <i>p</i> < 0.0001, OR = 1.56, 95% CI: 1.40-1.74; allele model: <i>p</i> < 0.0001, OR = 0.73, 95% CI: 0.69-0.78) variants were all significantly associated with the susceptibility to GDM.
|
30991439 |
2019 |
|
Gestational Diabetes
|
|
0.080 |
GeneticVariation
|
BEFREE |
In addition, we confirmed three variants, rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs4506565 (TCF7L2), that had previously been significantly associated with GDM risk.
|
29947923 |
2018 |
|
Gestational Diabetes
|
|
0.080 |
GeneticVariation
|
BEFREE |
The further meta-analysis included other five studies showed that the frequency of MTNR1B rs10830963 G allele and rs1387153 T allele are higher in GDM patients.
|
26563312 |
2016 |
|
Gestational Diabetes
|
|
0.080 |
GeneticVariation
|
BEFREE |
Our results showed a significant association between the three genetic variants and GD</span>M risk, rs10830963 with a P-value less than 0.0001, rs1387153 with a P-value of 0.0002, and rs1801278 with a P-value of 0.001.
|
25146448 |
2014 |