rs1407906280, MDM2

N. diseases: 3
Disease: Blast Phase ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Blast Phase
CUI: C0005699
Disease: Blast Phase
0.010 GeneticVariation BEFREE Here, we demonstrate that JNJ-26854165, an inhibitor of MDM2, inhibits proliferation and triggers cell death in a p53-independent manner in various BCR/ABL-expressing cells, which include primary leukemic cells from patients with CML blast crisis and cells expressing the Imatinib-resistant T315I BCR/ABL mutant. 27999193 2017