|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, weak correlations between 10 SNPs (CFH rs1329428 TT genotype, CFH rs3753394 CC genotype and T allele, CFH rs1410996 AA genotype, CFH rs800292 AA genotype, CFH rs800292 A allele, VEGF rs833061 TT genotype and C allele, VEGF rs2010963 CG genotype, VEGFR2 rs1531289 TT genotype, ARMS2 rs10490924 TT genotype, KCTD10 rs238104 GC genotype, rs1531289 T allele and ARMS2 rs10490924 T allele) and AMD were shown.
|
30696427 |
2019 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that CFH rs1061170 and rs1410996 polymorphisms were associated with AMD risk, both of which demonstrated a higher susceptibility to AMD, especially to nAMD.
|
26727378 |
2016 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Risk alleles of three SNPs, rs1061170 (CFH), rs1410996 (CFH), and rs10490924 (ARMS2) were found to be significantly associated with the AMD case/control status as defined by the algorithm.
|
26255974 |
2015 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results show that genotypes of ARMS2 (rs10490923), HTRA1 (rs112000638) and CFH (rs1410996) polymorphisms are related to an increased risk of suffering AMD in Spanish patients.
|
23534868 |
2014 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
In our study, two SNPs of CFH and their haplotypes were associated significantly with AMD, and the adjusted odd ratios (ORs) were 2.45 (95% confidence interval [CI] 1.25-4.79) for rs800292 (genotype GG versus AA), 2.49 (95% CI 1.24-5.00) for rs1410996 (genotype TT versus CC), and 4.45 (95% CI 2.32-8.55) for haplotype block of rs800292-rs1410996 (haplotype G-C versus A-C), respectively.
|
23233260 |
2013 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
GWASDB |
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
|
23326517 |
2013 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two common variants in the gene encoding complement factor H (CFH), the Y402H substitution (rs1061170, c.1204C>T)(1-4) and the intronic rs1410996 SNP(5,6), explain 17% of age-related macular degeneration (AMD) liability.
|
22019782 |
2011 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Variants in CFH rs1410996, ARMS2/HTRA1 A69S, and C3 R102G were significantly associated with an increased risk of AMD.
|
21906714 |
2011 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
This study showed that SNPs rs3753394 (P = 0.0276), rs800292 (P = 0.0266), rs1061170 (P = 0.00514), and rs1329428 (P = 0.0089), but not rs7535263, rs1410996, or rs2274700, in CFH were significantly associated with wet AMD in a mainland Han Chinese population.
|
20523265 |
2010 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
There was a possible association between LIPC and complement factor H (CFH) rs1410996, and a possible interaction effect between LIPC and both CFH rs10033900 and the complement factor I (CFI) variants in terms of risk of AMD.
|
21139980 |
2010 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The data suggest that the noncoding variant rs1410996 of the CFH gene moderately increased the risk of exudative AMD in a Chinese population.
|
19850835 |
2010 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
The interaction analysis between gene and environmental factors showed that smoking synergistically increased susceptibility of AMD for heterozygotes of rs1410996, with OR(interaction) of 7.33 (P(interaction) = 0.029).
|
19187590 |
2008 |
|
Age related macular degeneration
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although the Y402H variant was not significantly associated with AMD, other coding and noncoding variants in the CFH gene including rs1410996 and smoking moderately influenced the risk of AMD in a Japanese population.
|
17962488 |
2007 |
|
Blood Protein Measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Chronic Obstructive Airway Disease
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
response to bronchodilator
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
von Willebrand's factor (lab test)
|
|
0.700 |
GeneticVariation
|
GWASDB |
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
|
23381943 |
2013 |
|
Coagulation factor measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
|
23381943 |
2013 |
|
MACULAR DEGENERATION, AGE-RELATED, 4 (disorder)
|
|
0.700 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
|
Glycogen storage disease type II
|
|
0.030 |
GeneticVariation
|
BEFREE |
CFH (rs1410996), HTRA1 (rs112000638) and ARMS2 (rs10490923) gene polymorphisms are associated with AMD risk in Spanish patients.
|
23534868 |
2014 |
|
Glycogen storage disease type II
|
|
0.030 |
GeneticVariation
|
BEFREE |
The data suggest that the noncoding variant rs1410996 of the CFH gene moderately increased the risk of exudative AMD in a Chinese population.
|
19850835 |
2010 |
|
Glycogen storage disease type II
|
|
0.030 |
GeneticVariation
|
BEFREE |
The interaction analysis between gene and environmental factors showed that smoking synergistically increased susceptibility of AMD for heterozygotes of rs1410996, with OR(interaction) of 7.33 (P(interaction) = 0.029).
|
19187590 |
2008 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Lower C3d/C3 ratios were found for diabetes (p = 2.87 × 10(-6)), higher body mass index (p = 1.00 × 10(-13)), the SNPs rs1410996 (p = 0.0001), rs800292 (p = 0.003), rs12144939 (p = 4.60 × 10(-6)) in CFH, rs4151667 (p = 1.01 × 10(-5)) in CFB and individual haplotypes in CFH and CFB.
|
24675670 |
2014 |