|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
FTO genotypes associated with risk for obesity and loss of control of eating, specifically rs1421085, may interact with insecure attachment in a way that may exacerbate binge eating among women with BED.
|
30822753 |
2019 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
FTO SNPs rs1421085</span> and rs9939609 affect genetic susceptibility for obesity only in girls, whereas, SNP rs8057044 and CNV are associated with overweight status only in boys.
|
30537186 |
2019 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
The FTO SNP (rs1421085) results in a T to C nucleotide substitution that may result in an increased risk for obesity in individuals who carry at least one C allele.
|
30124167 |
2018 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
The FTO polymorphisms were associated with a significantly increased risk for obesity and in BMI-stratified cohort, rs9939609 (T/A: odds ratio [OR] = 1.73, p = 0.007) and rs1421085 (T/C: OR = 1.56, p = 0.03) showed even stronger association.
|
29466028 |
2018 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
BACKGROUND The distribution of fat mass and obesity-associated gene (FTO) genes rs9939609 and rs1421085 in obese and normal ethnic Mongolians was analyzed to investigate the association of FTO gene polymorphisms with obesity and metabolic syndrome in ethnic Mongolians.
|
30442880 |
2018 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
This indicates that the rs1421085-C allele in FTO induces obesity likely via other pathways than via reduced FatOx.
|
28626215 |
2017 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In single locus analysis, FTO rs8050136 CA (p = 0.0001; OR (95% CI) = 2.4 (1.7-3.4) and AA (p = 0.0001; OR (95% CI) = 3.1 (1.9-5.2); FTO rs1421085 TA (p = 0.0001; OR (95% CI) = 2.1 (1.4-3.0) and AA (p = 0.0001; OR (95% CI) = 3.0 (1.8-5.0); FTO rs9939609 TC (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and CC (p = 0.0001; OR (95% CI) = 4.2 (2.5-7.3) along with TG (p = 0.001; OR (95% CI) = 2.1 (1.3-3.2) and GG (p = 0.021; OR (95% CI) = 3.8 (1.2-11.8) genotypes of FTO rs17817449 with GT (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and TT (p = 0.012; OR (95% CI) = 3.3 (1.8-3.6) genotypes of IRX3 rs3751723 were significantly associated with obesity.
|
26440677 |
2016 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNPs rs1421085, rs17817449 and rs8043757 in the first intron of the FTO gene are associated with increasing risk of obesity in Thais.
|
25542809 |
2015 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
The FTO rs1421085 T>C polymorphism may modulate the magnitude of dyslipidemia in Chinese early-onset obesity.
|
24331679 |
2014 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene.
|
25074273 |
2014 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
|
23563609 |
2013 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
|
23563609 |
2013 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In case-control studies, both rs9939609 and rs1421085 polymorphisms were significantly associated with obesity (OR 1.97; 95% CI, 1.08-3.59; p = 0.026; OR 2.11; 95% CI, 1.17-3.81; p = 0.013, respectively) but not with overweight (p>0.05).
|
23342142 |
2013 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Obesity risk alleles at FTO rs1421085 significantly predicted more eating episodes per day (P = 0.001)-an effect that persisted after adjustment for body weight (P = 0.004).
|
22513296 |
2012 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, rs1421085, rs8050136 and rs9939609 were associated with obesity status and measures of obesity (BMI, waist circumference and waist-to-hip ratio) in stage 2 and combined study population.
|
21814223 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide population-based association study of extremely overweight young adults--the GOYA study.
|
21935397 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Significant associations were detected between obesity risk and the five polymorphisms: rs9939609 (OR: 1.31, 95% CI: 1.26 to 1.36), rs1421085 (OR: 1.43, 95% CI: 1.33 to 1.53), rs8050136 (OR: 1.25, 95% CI: 1.13 to 1.38), rs17817449 (OR: 1.54, 95% CI: 1.41 to 1.68), and rs1121980 (OR: 1.34, 95% CI: 1.10 to 1.62).
|
21651756 |
2011 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In African-Americans, only the rs1421085 C allele was a determinant of obesity risk (OR = 1.17, p = 0.05), but was found to be protective against diabetes (OR = 0.79, p = 0.03).
|
20502638 |
2010 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the present study, we analyzed independent and combined effects of the FTO rs1421085 and MC4R rs17782313 risk alleles on BMI, fat mass, prevalence and incidence of obesity and subsequent type 2 diabetes (T2D) as well as their interactions with physical activity levels and gender in two European prospective population-based cohorts of 4,762 Finnish adolescents (NFBC 1986) and 3,167 French adults (D.E.S.I.R.).
|
19255736 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
|
19151714 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both rs17782313 (near MC4R) and rs1421085 (FTO) polymorphisms have been consistently associated with increased risk of obesity and with body mass index (BMI) variation.
|
19153581 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
|
19151714 |
2009 |
|
Obesity
|
|
0.900 |
GeneticVariation
|
BEFREE |
In European populations, common variants (rs1421085-C, rs17817449-G, and rs9939609-A) in the fat mass and obesity (FTO associated) were recently found to be associated with body mass index (BMI) or obesity.
|
17928949 |
2007 |