rs1478604, THBS1

N. diseases: 9
Disease: Keratoconjunctivitis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Keratoconjunctivitis
CUI: C0022573
Disease: Keratoconjunctivitis
0.010 GeneticVariation BEFREE Carriers of the rs1478604 minor allele expressed significantly reduced levels of thrombospondin 1 (TSP1) (P = 0.042) and increased levels of an inflammatory cytokine associated with keratoconjunctivitis, interleukin-1β (P = 0.025), in their ocular surface epithelial cells compared with homozygous major allele controls. 24679443 2014