rs1495965, None

N. diseases: 8
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Behcet Syndrome
CUI: C0004943
Disease: Behcet Syndrome
0.820 GeneticVariation BEFREE An IL23R-IL12RB2 intergenic SNP rs1495965 was significantly associated with BD risk (OR (95% CI) = 1.5 (1.3, 1.7), P = 2.5 × 10<sup>-7</sup>) in the pooled meta-analysis of the discovery (1.4 (1.2, 1.7), P = 4.9 × 10<sup>-7</sup>) and replication (1.9 (1.3, 2.6), P = 6.0 × 10<sup>-4</sup>) phases. 29017598 2017
Behcet Syndrome
CUI: C0004943
Disease: Behcet Syndrome
0.820 GeneticVariation BEFREE SNPs rs10489629, rs1343151, and rs1495965 were also significantly associated with BD in all tests performed. 22378604 2012
Behcet Syndrome
CUI: C0004943
Disease: Behcet Syndrome
0.820 GeneticVariation GWASCAT Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. 20622879 2010
Behcet Syndrome
CUI: C0004943
Disease: Behcet Syndrome
0.820 GeneticVariation GWASDB Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. 20622879 2010
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.720 GeneticVariation BEFREE Patients with the homozygous G allele of rs1495965 showed higher CD risk than those with other genotypes (GG vs. AA: OR, 2.256; 95% CI, 1.136-4.478; <i>p</i> = 0.019; GG vs. GA+AA: OR, 2.000; 95% CI, 1.175-3.404; <i>p</i> = 0.010). 31799225 2019
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.720 GeneticVariation BEFREE Two IL23R gene variants, an intronic SNP rs1004819 and intergenic SNP rs1495465, showed significant associations with CD; the adjusted odds ratio (aOR) for rs1004819 was 1.822 (95% confidence interval [CI] = 1.164-2.852, P = 0.009) and aOR for rs1495965 was 1.650 (95% CI = 1.102-2.471, P = 0.015). 19334001 2009
Crohn Disease
CUI: C0010346
Disease: Crohn Disease
0.720 GeneticVariation GWASDB A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. 17068223 2006
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.020 GeneticVariation BEFREE However, subgroup analysis failed to unveil any association between the rs1495965 and rs1343151 polymorphisms and UC in Caucasians or Asians. 27902482 2017
Ulcerative Colitis
CUI: C0009324
Disease: Ulcerative Colitis
0.020 GeneticVariation BEFREE Moreover, meta-analysis revealed no association between the four alleles of the rs2201841, rs1004819, rs1495965 and rs1343151 polymorphisms and the risk of developing UC in Caucasian and Asian populations. 25497273 2015
Inflammatory Bowel Diseases
CUI: C0021390
Disease: Inflammatory Bowel Diseases
0.020 GeneticVariation BEFREE Seven single nucleotide polymorphisms (rs1004819, rs7517847, rs10489629, rs2201841, rs1343151, rs11209032, and rs1495965) were selected for genotyping among previously reported variants used in a genome-wide association study of inflammatory bowel disease. 19306001 2009
Inflammatory Bowel Diseases
CUI: C0021390
Disease: Inflammatory Bowel Diseases
0.020 GeneticVariation BEFREE Eight IL23R gene polymorphisms (rs1,004,819, rs7,517,847, rs10,489,629, rs11,209,026, rs1,343,151, rs10,889,677, rs11,209,032, and rs1,495,965) were selected among the 10 most associated SNPs from the IBD study. 17678723 2007
Behcet's uveitis
CUI: C3160901
Disease: Behcet's uveitis
0.010 GeneticVariation BEFREE Single-Nucleotide Polymorphisms in IL23R-IL12RB2 (rs1495965) Are Highly Prevalent in Patients with Behcet's Uveitis and Vary Between Populations. 29792538 2019
Ankylosing spondylitis
CUI: C0038013
Disease: Ankylosing spondylitis
0.010 GeneticVariation BEFREE The present study indicates that minor allele carriers of rs1004819, rs1495965, and rs2201841 are susceptible to AS. 29944013 2018
Anterior uveitis
CUI: C0042165
Disease: Anterior uveitis
0.010 GeneticVariation BEFREE Four functional polymorphisms (rs3821236, rs7574865, rs7574070, and rs897200) located within STAT4 gene as well as three independent polymorphisms (rs7517847, rs11209026, and rs1495965) located within IL23R were genotyped using TaqMan® allelic discrimination in a total of 206 patients with non-anterior uveitis and 1553 healthy controls from Spain. 24312163 2013
Acute anterior uveitis
CUI: C0701807
Disease: Acute anterior uveitis
0.010 GeneticVariation BEFREE Four functional polymorphisms (rs3821236, rs7574865, rs7574070, and rs897200) located within STAT4 gene as well as three independent polymorphisms (rs7517847, rs11209026, and rs1495965) located within IL23R were genotyped using TaqMan® allelic discrimination in a total of 206 patients with non-anterior uveitis and 1553 healthy controls from Spain. 24312163 2013