|
Active tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analyses were conducted to test for main effects of vitamin D status and SNPs in VDR (rs731236, rs2228570 and rs1544410), DBP (rs7041 and rs4588) and CYP2R1 (rs2060793, rs10500804 and rs10766197) on susceptibility to TB, and to investigate whether these SNPs modify the association between vitamin D status and disease susceptibility.
|
27160686 |
2016 |
|
Adolescent idiopathic scoliosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of vitamin D receptor BsmI rs1544410 and ApaI rs7975232 polymorphisms with susceptibility to adolescent idiopathic scoliosis: A systematic review and meta-analysis.
|
29480871 |
2018 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the frequency of the VDR polymorphisms rs731236 (TaqI), rs7975232 (ApaI), rs10735810 (FokI) and rs1544410 (BsmI) in the AD group vs the healthy group.
|
26093050 |
2015 |
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Finally, rs1544410 polymorphism within the VDR gene, E2 and E4 alleles within the apoE gene, rs6254 polymorphism within the PTH gene, and rs1800871 polymorphism within the IL10 gene may be associated with aortic stenosis with low level of evidence.
|
24903972 |
2014 |
|
Aplastic Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequencies of GG genotype and G allele of rs1544410 were significantly higher in patients with AA than in controls.
|
27018192 |
2016 |
|
Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The clinical characteristics of BD patients were evaluated and patients with ocular lesions had a higher percentage of rs1544410 A alleles (p = 0.004), and patients with oral aphthous lesions, a positive pathergy tests, and arthritis had more rs2228570 C alleles than patients without these clinical findings (respectively, p < 0.001, p = 0.021, p = 0.045).
|
30730049 |
2019 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In subgroup analyses by type of disease, we confirmed positive results for rs1544410 BsmI polymorphism in both asthma and atopic dermatitis, and for rs731236 TaqI polymorphism in atopic dermatitis.
|
31752548 |
2020 |
|
Asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis was performed to identify whether VDR gene polymorphisms (FokI (rs2228570) or TaqI (rs731236) or BsmI (rs1544410) or ApaI (rs7975232)) play a role in the risk of asthma.
|
31654764 |
2020 |
|
Autism Spectrum Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
This case-control study aimed to determine the association of single-nucleotide polymorphisms (SNPs) rs731276 (TaqI), rs1568820 (Cdx2), rs1544410 (BsmI), and rs2228570 (FokI) in the vitamin D receptor (VDR) gene with susceptibility of childhood ASD and severity of the disease.
|
29581796 |
2018 |
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We study the association between three Vitamin D receptor gene polymorphisms (rs10735810, rs1544410, rs731236) and susceptibility to thyroid autoimmune diseases.
|
17943423 |
2008 |
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation
|
BEFREE |
<i>VDR</i> rs1544410 polymorphism was associated with a reduced risk of AITD in European and African populations, but with an increased risk of AITD in Asian populations.
|
29765404 |
2018 |
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The clinical characteristics of BD patients were evaluated and patients with ocular lesions had a higher percentage of rs1544410 A alleles (p = 0.004), and patients with oral aphthous lesions, a positive pathergy tests, and arthritis had more rs2228570 C alleles than patients without these clinical findings (respectively, p < 0.001, p = 0.021, p = 0.045).
|
30730049 |
2019 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Sunlight measures were not associated with breast cancer risk, however significant interactions between time outdoors in the teen years and three unlinked genotypes were found for VDR (rs1544410, rs2228570) and CYP24A1 (rs1570669).
|
23393347 |
2013 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Two common single nucleotide polymorphisms (SNPs) in the VDR gene, rs1544410 (BsmI) and rs2228570 (FokI), are inconsistently associated with breast cancer risk in Caucasian populations, while data for Asians are scarce.
|
26517870 |
2015 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
No association was noted between rs1544410 (BsmI) BB and breast cancer risk overall (OR, 0.98; 95% CI, 0.89-1.09), but the BB genotype was associated with a significantly lower risk of advanced breast cancer (OR, 0.74; 95% CI, 0.60-0.92).
|
19124512 |
2009 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The TCTCTG-rs9533156-rs2073618-rs2073617-rs4950928-rs2228570-rs1544410 haplotype was significantly associated with increased BC </span>risk (adjusted odds ratio = 8.33; 95% confidence interval, 1.32-52.46; P = .025) compared with controls.
|
30309792 |
2019 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Association of FokI (rs2228570) and BsmI (rs1544410) single nucleotide polymorphisms (SNPs) in VDR gene with the risk of breast cancer have been investigated in several studies, however, the published data are still inconsistent.
|
28780723 |
2018 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The most extensively studied SNPs including rs10735810, also known as rs2228570 (Fok1, VDR), rs1544410 (Bsm1, VDR), and rs2296241 (CYP24A1), were not associated with breast cancer risk.
|
21828234 |
2011 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
The role of the rs1544410 polymorphism of vitamin D receptor gene in breast cancer susceptibility.
|
25064221 |
2014 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
The first aim of our study was to examine the association between common variants in VDR [rs2228570 (FokI), rs1544410 (BsmI), rs7975232 (ApaI), rs731236 (TaqI) and rs11568820 (Cdx2)] and lung cancer risk in the Polish population.
|
28411367 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
|
0.020 |
GeneticVariation
|
BEFREE |
The association of ovarian cancer risk with polymorphisms in the vitamin D receptor (VDR) gene, including rs10735810 (FokI), rs11568820 (Cdx-2), rs1544410 (BsmI), rs7975232 (ApaI), rs731236 (TaqI), and BsmI-ApaI-TaqI combined genotypes, was examined among 313 women with epithelial ovarian carcinoma and 574 controls.
|
18086759 |
2007 |
|
Carcinoma, Ovarian Epithelial
|
|
0.020 |
GeneticVariation
|
BEFREE |
Moreover, for detecting clinical risk of OC, heterozygote models with the rs1544410 (BsmI) polymorphism is likely the best genetic model for detecting the risk of OC in Caucasian patients.
|
30059751 |
2018 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
To assess the association between vitamin D-Binding Protein (VDBP rs7041T>G) and vitamin D receptor (VDR rs1544410G>A) gene polymorphisms with susceptibility to cardiovascular diseases in population from west of Iran.
|
31359379 |
2019 |
|
Childhood asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A systematic review was conducted on the relationship between childhood asthma and VDR gene polymorphisms, including ApaI (rs7975232), BsmI (rs1544410), FokI (rs2228570), and TaqI (rs731236).
|
27551963 |
2017 |
|
Chlamydia Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study assesses the impact of eight polymorphisms in five genes [VDR (rs1544410 G > A, rs2228570 C > T), CYP27B1 (rs10877012 G > T), DHCR7 (rs7944926 G > A, rs3829251 G > A), GC (rs3755967) and CYP2R1 (rs10741657 G > A, rs2060793 G > A)] on susceptibility to Chlamydia infections in humans.
|
26867646 |
2016 |